Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | MITF | O75030 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20334886 | 0.82 | NPC1 (1.00) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL11202999 | 0.78 | KMT2A (0.57) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL23094166 | 0.74 | NPC1 (1.00) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL21467691 | 0.74 | MAPT (0.81) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7334283 | 0.74 | ALDH1A1 (0.62) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL12652713 | 0.73 | NPC1 (0.81) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL13504941 | 0.73 | NPC1 (0.81) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL7343483 | 0.73 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL10617441 | 0.71 | MEN1 (0.58) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL1426369 | 0.70 | ADAM17 (0.60) | ALDH1A1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048563-A1 | SUBSTITUTED INDOLEPYRIDINIUM AS ANTI-INFECTIVE COMPOUNDS | KESTELEYN BART RUDOLF ROMANIE | 2010-02-25 | — | — | US | disclosed |
| US-20100029635-A1 | 6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS | KESTELEYN BART RUDOLF ROMANIE | 2010-02-04 | — | — | US | disclosed |
| US-7622581-B2 | 6,7,8,9-substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2009-11-24 | — | — | US | disclosed |
| US-7608726-B2 | 5-(2-Morpholin-4-yl-ethyl)-1-(4-nitro-phenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile; 5-isobutyl-1-(4-nitro-phenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile; anti-retroviral agent | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2009-10-27 | — | — | US | disclosed |
| US-20070249655-A1 | 4-Substituted-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones | KESTELEYN BART R R | 2007-10-25 | — | — | US | disclosed |
| US-20070238727-A1 | 5-Substituted 1-Phenyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones and Analogs as Anti-Virals | TIBOTEC BVBA (BE) | 2007-10-11 | — | — | US | disclosed |
| US-20070167434-A1 | 6,7,8,9-Substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | TIBOTEC BVBA (BE) | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249655-A1 | 4-Substituted-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones | CYP8B1, CYP2S1, CYC1 | ALDH1A1 954/4885MEN1 2135/4885KMT2A 2382/4885 |
| US-20100029635-A1 | 6,7,8,9-SUBSTITUTED 1-PHENYL-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES USEFUL AS ANTI-INFECTIVE PHARMACEUTICAL AGENTS | HRH4, CBR1, HRH2 | ALDH1A1 1714/4885MEN1 3953/4885KMT2A 3815/4885 |
| US-20070167434-A1 | 6,7,8,9-Substituted 1-phenyl-1,5-dihydro-pyrido[3,2-b]indol-2-ones useful as anti-infective pharmaceutical agents | HRH4, CBR1, HRH2 | ALDH1A1 1535/4885MEN1 3835/4885KMT2A 3899/4885 |
| US-20070238727-A1 | 5-Substituted 1-Phenyl-1,5-Dihydro-Pyrido[3,2-B]Indol-2-Ones and Analogs as Anti-Virals | NR5A2, NR5A1, NR4A1 | ALDH1A1 1204/4885MEN1 3984/4885KMT2A 2832/4885 |
| US-20100048563-A1 | SUBSTITUTED INDOLEPYRIDINIUM AS ANTI-INFECTIVE COMPOUNDS | LTC4S, CYP8B1, CYP2E1 | ALDH1A1 995/4885MEN1 1516/4885KMT2A 3943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.