Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOD1 | P00441 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3922161 | 0.88 | ALDH1A1 (0.48) | SOD1PDK2ALDH1A1RECQLCYP4F2 | |
| SCHEMBL24217691 | 0.86 | EPAS1 (0.42) | PDK2TP53 | |
| SCHEMBL16493129 | 0.86 | ESRRG (0.34) | PDK2TP53ALOX15ALDH1A1RECQL | |
| SCHEMBL24217690 | 0.86 | KCNH2 (0.35) | SOD1PDK2TP53ALOX15ALDH1A1 | |
| SCHEMBL2759034 | 0.83 | ALDH1A1 (0.44) | PDK2TP53ALOX15ALDH1A1RECQL | |
| SCHEMBL28920062 | 0.81 | APP (0.45) | SOD1ALDH1A1RECQL | |
| SCHEMBL16471655 | 0.81 | TP53 (0.35) | PDK2TP53ALOX15ALDH1A1 | |
| SCHEMBL3290620 | 0.79 | FFAR1 (0.47) | PDK2ALDH1A1RECQL | |
| SCHEMBL4023626 | 0.79 | SOD1 (0.40) | SOD1 | |
| SCHEMBL18116610 | 0.78 | SOD1 (0.42) | SOD1CYP4F2CYP4A11CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115109022-A | Preparation method of 5, 7-difluorochroman-4-one | 常州工程职业技术学院 | 2022-09-27 | — | — | CN | claimed |
| CN-121426650-A | Tergolian medicine intermediate and preparation method thereof | 四川定科制药有限公司 | 2026-01-30 | — | — | CN | disclosed |
| CN-118852079-A | Method for synthesizing tergolian intermediate 5, 7-difluoro chroman-4-ketone | 浙江中科创越药业有限公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-117986220-A | Method for preparing substituted chromanone derivative | 杭州杜易科技有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-114222734-B | Method for preparing substituted chromanone derivative | 杭州杜易科技有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-115109022-A | Preparation method of 5, 7-difluorochroman-4-one | 常州工程职业技术学院 | 2022-09-27 | — | — | CN | disclosed |
| US-11377434-B2 | Methods for preparing substituted chromanone derivatives | HANGZHOU DUYI TECHNOLOGY CO. LTD. (CN) | 2022-07-05 | — | — | US | disclosed |
| CN-114222734-A | Method for preparing substituted chromanone derivative | 杭州杜易科技有限公司 | 2022-03-22 | — | — | CN | disclosed |
| US-20220024890-A1 | METHODS FOR PREPARING SUBSTITUTED CHROMANONE DERIVATIVES | HANGZHOU DUYI TECHNOLOGY CO. LTD. (CN) | 2022-01-27 | — | — | US | disclosed |
| WO-2022016309-A1 | METHODS FOR PREPARING SUBSTITUTED CHROMANONE DERIVATIVES | HANGZHOU DUYI TECHNOLOGY CO. LTD. (CN) | 2022-01-27 | — | — | WO | disclosed |
| US-8063234-B2 | Substituted 7-sulfanylmethyl-, 7-sulfinylmethyl- and 7-sulfonylmethylindoles and the use thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-11-22 | — | — | US | disclosed |
| US-8063234-B2 | Substituted 7-sulfanylmethyl-, 7-sulfinylmethyl- and 7-sulfonylmethylindoles and the use thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-11-22 | — | — | US | disclosed |
| US-8063234-B2 | Substituted 7-sulfanylmethyl-, 7-sulfinylmethyl- and 7-sulfonylmethylindoles and the use thereof | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-11-22 | — | — | US | disclosed |
| US-20110201564-A1 | SUBSTITUTED 7-SULFANYLMETHYL, 7-SULFINYLMETHYL AND 7-SULFONYLMETHYL INDOLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-08-18 | — | — | US | disclosed |
| US-20110201564-A1 | SUBSTITUTED 7-SULFANYLMETHYL, 7-SULFINYLMETHYL AND 7-SULFONYLMETHYL INDOLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-08-18 | — | — | US | disclosed |
| US-20110201564-A1 | SUBSTITUTED 7-SULFANYLMETHYL, 7-SULFINYLMETHYL AND 7-SULFONYLMETHYL INDOLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-08-18 | — | — | US | disclosed |
| US-20100105744-A1 | SUBSTITUTED 7-SULFANYLMETHYL-, 7-SULFINYLMETHYL- AND 7-SULFONYLMETHYLINDOLES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-29 | — | — | US | disclosed |
| US-20100105744-A1 | SUBSTITUTED 7-SULFANYLMETHYL-, 7-SULFINYLMETHYL- AND 7-SULFONYLMETHYLINDOLES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-29 | — | — | US | disclosed |
| US-20100105744-A1 | SUBSTITUTED 7-SULFANYLMETHYL-, 7-SULFINYLMETHYL- AND 7-SULFONYLMETHYLINDOLES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-04-29 | — | — | US | disclosed |
| WO-2009156072-A1 | SUBSTITUTED 7-SULFANYLMETHYL, 7-SULFINYLMETHYL AND 7-SULFONYLMETHYL INDOLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105744-A1 | SUBSTITUTED 7-SULFANYLMETHYL-, 7-SULFINYLMETHYL- AND 7-SULFONYLMETHYLINDOLES AND THE USE THEREOF | STS, HTR7, PCSK7 | SOD1 1188/4885PDK2 963/4885TP53 4271/4885 |
| US-20110201564-A1 | SUBSTITUTED 7-SULFANYLMETHYL, 7-SULFINYLMETHYL AND 7-SULFONYLMETHYL INDOLES AND USE THEREOF | HTR7, STS, INMT | SOD1 2130/4885PDK2 1227/4885TP53 3623/4885 |
| US-20220024890-A1 | METHODS FOR PREPARING SUBSTITUTED CHROMANONE DERIVATIVES | CBR3, CYP2F1, CBR1 | SOD1 276/4885PDK2 273/4885TP53 1590/4885 |
| US-11377434-B2 | Methods for preparing substituted chromanone derivatives | CYP2E1, CYP2F1, CBR1 | SOD1 275/4885PDK2 274/4885TP53 1557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.