Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOD1 | P00441 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1347871 | 0.79 | SOD1 (0.39) | SOD1 | |
| SCHEMBL9242292 | 0.79 | LTA4H (0.45) | — | |
| SCHEMBL5976371 | 0.79 | SOD1 (0.39) | SOD1DRD2DRD4DRD3IDO1 | |
| SCHEMBL3064784 | 0.79 | SOD1 (0.39) | SOD1DRD2DRD4DRD3IDO1 | |
| SCHEMBL5659153 | 0.79 | MAOB (0.45) | — | |
| SCHEMBL7823301 | 0.77 | SOD1 (0.38) | SOD1KCNA3 | |
| SCHEMBL18205445 | 0.77 | RAB9A (0.31) | DRD2DRD4DRD3MAPTKCNA3 | |
| SCHEMBL3054211 | 0.76 | SOD1 (0.40) | SOD1IDO1MAPTKDM1AFGFR1 | |
| SCHEMBL3922161 | 0.76 | ALDH1A1 (0.48) | SOD1 | |
| SCHEMBL6793710 | 0.76 | KAT6A (0.43) | SOD1FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |