Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24608083 | 0.90 | KCNH2 (0.33) | KCNH2 | |
| SCHEMBL29779784 | 0.86 | PTPN1 (0.32) | NCEH1PTPN1 | |
| SCHEMBL16317225 | 0.82 | NCEH1 (0.30) | NCEH1 | |
| SCHEMBL28974945 | 0.80 | GABRA1 (0.36) | TRPA1ATMALDH1A1 | |
| SCHEMBL16707468 | 0.79 | SCN5A (0.35) | NCEH1TRPA1ATM | |
| SCHEMBL147382 | 0.79 | MAPT (0.47) | TRPA1ATMKCNH2ALDH1A1 | |
| SCHEMBL28306903 | 0.77 | MAPT (0.46) | TRPA1ATMKCNH2 | |
| SCHEMBL28974998 | 0.77 | TRPA1 (0.38) | TRPA1ATMKCNH2ALDH1A1 | |
| SCHEMBL15310018 | 0.77 | — | — | |
| SCHEMBL11553756 | 0.75 | KCNH2 (0.43) | TRPA1ATMKCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | NCEH1 62/4885TRPA1 4872/4885ATM 4180/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | NCEH1 56/4885TRPA1 4834/4885ATM 4041/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.