Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 6/20 | 0.65 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13490806 | 0.96 | MTNR1B (0.59) | MTNR1BMTNR1AALDH1A1NPC1RECQL | |
| SCHEMBL13411722 | 0.84 | MTNR1A (0.70) | MTNR1BMTNR1AALDH1A1NPC1RECQL | |
| SCHEMBL18183526 | 0.78 | SMN1; SMN2 (0.70) | MTNR1BMTNR1ASMN1; SMN2CNR1CNR2 | |
| SCHEMBL13490807 | 0.76 | CNR1 (0.44) | ALDH1A1RECQLTSHRCNR1CNR2 | |
| SCHEMBL13490816 | 0.76 | FFAR1 (0.54) | CNR1CNR2 | |
| SCHEMBL13490817 | 0.75 | CNR1 (0.51) | ALDH1A1SMN1; SMN2CNR1CNR2MAPT | |
| SCHEMBL1911330 | 0.74 | ALDH1A1 (0.42) | ALDH1A1TSHRMAPK1CNR1CNR2 | |
| SCHEMBL5670829 | 0.74 | TACR1 (0.55) | MTNR1BMTNR1AALDH1A1SMN1; SMN2 | |
| SCHEMBL89065 | 0.73 | NPC1 (0.57) | ALDH1A1NPC1RECQLRAB9ASMN1; SMN2 | |
| SCHEMBL88823 | 0.73 | ALDH1A1 (0.61) | ALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029647-A1 | 3,4,(5)-SUBSTITUTED TETRAHYDROPHYRIDINES | NOVARTIS AG (CH) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029647-A1 | 3,4,(5)-SUBSTITUTED TETRAHYDROPHYRIDINES | REN, PAH, ACE | MTNR1B 738/4885MTNR1A 1360/4885ALDH1A1 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.