Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 4/20 | 0.43 |
| ▸ | CNR2 | P34972 | 4/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14832413 | 0.86 | BRD4 (0.47) | BRD4SMN1; SMN2MAPK1L3MBTL1TSHR | |
| SCHEMBL13490812 | 0.84 | PPARA (0.49) | SMN1; SMN2MAPK1L3MBTL1ALDH1A1PPARG | |
| SCHEMBL13490816 | 0.84 | FFAR1 (0.54) | CNR1CNR2FFAR1PPARGPPARD | |
| SCHEMBL229166 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2CNR1CNR2PPARGPPARA | |
| SCHEMBL12698684 | 0.81 | ALDH1A1 (0.67) | BRD4MAPK1L3MBTL1TSHRTDP1 | |
| SCHEMBL1052227 | 0.81 | PTGS2 (0.50) | SMN1; SMN2CNR1CNR2PPARGPPARA | |
| SCHEMBL8981963 | 0.80 | BRD4 (0.56) | BRD4L3MBTL1CYSLTR2CYSLTR1LTA4H | |
| SCHEMBL13008060 | 0.80 | MAPT (0.47) | TSHRALDH1A1LTA4HPPARGPPARA | |
| SCHEMBL28396646 | 0.80 | PPARA (0.68) | BRD4CYSLTR2CYSLTR1FFAR1PPARG | |
| SCHEMBL13490817 | 0.80 | CNR1 (0.51) | SMN1; SMN2ALDH1A1CNR1CNR2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029647-A1 | 3,4,(5)-SUBSTITUTED TETRAHYDROPHYRIDINES | NOVARTIS AG (CH) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029647-A1 | 3,4,(5)-SUBSTITUTED TETRAHYDROPHYRIDINES | REN, PAH, ACE | BRD4 344/4885SMN1; SMN2 2582/4885MAPK1 2507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.