Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | BMI1 | P35226 | 2/20 | 0.43 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | HPD | P32754 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13495669 | 0.86 | PTGS2 (0.51) | POLBPTGS2GSRALDH3A1NR1H2 | |
| SCHEMBL13495638 | 0.85 | PTGS2 (0.47) | POLBPTGS2GSRALDH3A1 | |
| SCHEMBL13495634 | 0.82 | POLB (0.44) | HTTLMNASMN1; SMN2POLBPTGS2 | |
| SCHEMBL13495671 | 0.80 | POLB (0.42) | HTTSMN1; SMN2POLBPTGS2GSR | |
| SCHEMBL13495635 | 0.80 | ALDH1A1 (0.43) | POLBGSRALDH3A1MAPK1 | |
| SCHEMBL13495653 | 0.77 | MAPK1 (0.66) | HTTSMN1; SMN2POLBGSRALDH3A1 | |
| SCHEMBL13495748 | 0.77 | PIK3CA (0.54) | HTTPOLBBMI1GSRMAPK1 | |
| SCHEMBL13495693 | 0.77 | TSHR (0.49) | HTTSMN1; SMN2POLBCHEK1ATR | |
| SCHEMBL13495692 | 0.77 | GAA (0.42) | POLBPTGS2GSRALDH3A1HPD | |
| SCHEMBL3052790 | 0.77 | MAPK1 (0.65) | HTTSMN1; SMN2POLBGSRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010012745-A2 | BENZIMIDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-04 | — | — | WO | disclosed |