Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 8/20 | 0.39 |
| ▸ | MMP13 | P45452 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13500158 | 0.97 | ALDH1A1 (0.40) | MMP1MMP13ALDH1A1KMT2ALTA4H | |
| SCHEMBL13500291 | 0.97 | MMP1 (0.42) | MMP1MMP13ALDH1A1KMT2ALTA4H | |
| SCHEMBL13500292 | 0.97 | ALDH1A1 (0.40) | MMP1MMP13ALDH1A1KMT2ALTA4H | |
| SCHEMBL13500299 | 0.95 | ALDH1A1 (0.41) | MMP1MMP13ALDH1A1KMT2ALTA4H | |
| SCHEMBL13500153 | 0.95 | MMP1 (0.37) | MMP1MMP13ALDH1A1KMT2ALTA4H | |
| SCHEMBL8288403 | 0.93 | ALDH1A1 (0.43) | MMP1MMP13ALDH1A1KMT2ALTA4H | |
| SCHEMBL13499664 | 0.85 | LTA4H (0.45) | MMP1MMP13ALDH1A1KMT2ALTA4H | |
| SCHEMBL13501740 | 0.85 | ALDH1A1 (0.44) | MMP1MMP13ALDH1A1KMT2ALTA4H | |
| SCHEMBL13435021 | 0.84 | CPB2 (0.41) | MMP1MMP13ALDH1A1KMT2ALTA4H | |
| SCHEMBL13461536 | 0.84 | ALDH1A1 (0.39) | MMP1MMP13ALDH1A1KMT2ALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655647-B2 | Substituted lactams as inhibitors of Aβ protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2010-02-02 | — | — | US | disclosed |
| US-20100009966-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009966-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION | BACE1, APP, APH1A | MMP1 2106/4885MMP13 2668/4885ALDH1A1 3896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.