SCHEMBL13502568

SCHEMBL13502568

ClC[C@@H]1CO[C@@](Br)(c2ccc(Oc3ccccc3)cc2)O1

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 10/20 0.36
ADRA1A P35348 9/20 0.36
ADRA1B P35368 9/20 0.36
ADRA1D P25100 7/20 0.36
CNR2 P34972 1/20 0.34
TDP1 Q9NUW8 1/20 0.33
UTS2R Q9UKP6 1/20 0.33
LTA4H P09960 1/20 0.32
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12662787 0.87 GRIN1 (0.36) HTR1AADRA1AADRA1BADRA1D
SCHEMBL13502571 0.85 HTR1A (0.34) HTR1AADRA1AADRA1BADRA1D
SCHEMBL12132824 0.84 HTR1A (0.35) HTR1AADRA1AADRA1BADRA1DCNR2
SCHEMBL12132826 0.84 HTR1A (0.35) HTR1AADRA1AADRA1BADRA1DCNR2
SCHEMBL12132821 0.84 ADRA1A (0.36) HTR1AADRA1AADRA1BADRA1DCNR2
SCHEMBL13502575 0.83 MAOB (0.36) HTR1AADRA1AADRA1BADRA1D
SCHEMBL12661565 0.80 SLC6A4 (0.39) UTS2R
SCHEMBL13502567 0.79 HSD11B1 (0.33)
SCHEMBL13502565 0.79 HSP90AA1 (0.38)
SCHEMBL8493053 0.73 LTA4H (0.44) UTS2RLTA4HTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010013510-A1 PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE COMPOUND ダイソー株式会社 (JP) 2010-02-04 WO disclosed