Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3754049 | 0.78 | GAA (0.33) | RIPK1P2RX7ALKBH1GPR119NTRK1 | |
| SCHEMBL13504501 | 0.76 | CACNA1H (0.41) | ALDH1A1 | |
| SCHEMBL2661612 | 0.74 | ALKBH1 (0.41) | RIPK1P2RX7ALKBH1MEN1KMT2A | |
| SCHEMBL3743369 | 0.71 | AR (0.43) | P2RX7CYP3A4CYP2D6MAPT | |
| SCHEMBL27587624 | 0.68 | AKR1B1 (0.38) | KDM4EALDH1A1AKR1B1POLBGAA | |
| SCHEMBL20090412 | 0.66 | RIPK1 (0.44) | RIPK1P2RX7GPR119CYP1A2ALDH1A1 | |
| SCHEMBL4677240 | 0.66 | KDM4A (0.42) | RIPK1MEN1KMT2AKDM4AKDM5A | |
| SCHEMBL12780284 | 0.66 | CES2 (0.61) | MEN1KMT2AALDH1A1GAA | |
| SCHEMBL9714289 | 0.65 | CA5A (0.45) | ALKBH1KDM4AKDM5AKDM4CKDM5B | |
| SCHEMBL28008353 | 0.64 | CYP11B1 (0.46) | MEN1KMT2AKDM4EALDH1A1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299115-B2 | Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2012-10-30 | — | — | US | disclosed |