Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3936533 | 1.00 | LMNA (0.61) | LMNAGAAPKMALDH1A1MAPT | |
| SCHEMBL1352768 | 0.90 | ALDH1A1 (0.59) | LMNAGAAPKMALDH1A1MAPT | |
| SCHEMBL1351772 | 0.88 | ALDH1A1 (0.52) | LMNAGAAPKMALDH1A1MAPT | |
| SCHEMBL1351495 | 0.88 | ALDH1A1 (0.61) | LMNAGAAPKMALDH1A1MAPT | |
| SCHEMBL1350184 | 0.86 | MEN1 (0.73) | LMNAGAAPKMALDH1A1MAPT | |
| SCHEMBL1350186 | 0.86 | MEN1 (0.73) | LMNAGAAPKMALDH1A1MAPT | |
| SCHEMBL1350523 | 0.86 | ALDH1A1 (0.58) | LMNAGAAPKMALDH1A1MAPT | |
| SCHEMBL1351928 | 0.83 | NPC1 (0.63) | LMNAGAAPKMALDH1A1MAPT | |
| SCHEMBL1351929 | 0.83 | NPC1 (0.63) | LMNAGAAPKMALDH1A1MAPT | |
| SCHEMBL1353299 | 0.82 | MEN1 (0.68) | LMNAGAAPKMALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2759540-A2 | Beta-3 receptor ligands and their use in therapy | Universita' Degli Studi di Bari (IT) | 2014-07-30 | — | — | EP | claimed |
| US-8354412-B2 | Beta-3 receptor ligands and their use in therapy | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2013-01-15 | — | — | US | claimed |
| US-20110288104-A1 | Beta-3 receptor ligands and their use in therapy | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2011-11-24 | — | — | US | claimed |
| US-20100075977-A1 | BETA-3 RECEPTOR LIGANDS AND THEIR USE IN THERAPY | UNVERSITA' DEGLI STUDI DI BARI (IT) | 2010-03-25 | — | — | US | claimed |
| EP-2759540-A2 | Beta-3 receptor ligands and their use in therapy | Universita' Degli Studi di Bari (IT) | 2014-07-30 | — | — | EP | disclosed |
| US-8354412-B2 | Beta-3 receptor ligands and their use in therapy | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2013-01-15 | — | — | US | disclosed |
| US-20110288104-A1 | Beta-3 receptor ligands and their use in therapy | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2011-11-24 | — | — | US | disclosed |
| US-8017613-B2 | Beta-3 receptor ligands and their use in therapy | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2011-09-13 | — | — | US | disclosed |
| US-20100075977-A1 | BETA-3 RECEPTOR LIGANDS AND THEIR USE IN THERAPY | UNVERSITA' DEGLI STUDI DI BARI (IT) | 2010-03-25 | — | — | US | disclosed |
| EP-2046722-A2 | BETA-3 RECEPTOR LIGANDS AND THEIR USE IN THERAPY | Universita' Degli Studi di Bari (IT) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008015558-A2 | BETA-3 RECEPTOR LIGANDS AND THEIR USE IN THERAPY | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075977-A1 | BETA-3 RECEPTOR LIGANDS AND THEIR USE IN THERAPY | ADRB3, ADRB2, ADRB1 | LMNA 1156/4885GAA 3398/4885PKM 3729/4885 |
| US-20110288104-A1 | Beta-3 receptor ligands and their use in therapy | ADRB3, ADRB2, ADRB1 | LMNA 1156/4885GAA 3398/4885PKM 3729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.