Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HPGDS | O60760 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1574742 | 0.82 | HDAC1 (0.66) | HDAC1HDAC8HDAC6TDP1CTSK | |
| SCHEMBL2529363 | 0.79 | CTSK (0.62) | HDAC1HDAC8HDAC6TDP1CTSK | |
| SCHEMBL2529359 | 0.79 | CTSK (0.62) | HDAC1HDAC8HDAC6TDP1CTSK | |
| SCHEMBL7692307 | 0.79 | CTSK (0.62) | HDAC1HDAC8HDAC6TDP1CTSK | |
| SCHEMBL352152 | 0.78 | HPGDS (0.73) | HDAC1HDAC8HDAC6TDP1HPGD | |
| SCHEMBL27768678 | 0.78 | HDAC1 (0.70) | HDAC1HDAC8HDAC6TDP1HPGD | |
| SCHEMBL3612948 | 0.77 | HDAC1 (0.59) | HDAC1HDAC8HDAC6TDP1CTSK | |
| Hydrochloric Acid SCHEMBL6821751 | 0.76 | HPGDS (0.71) | HDAC1HDAC8HDAC6TDP1HPGD | |
| SCHEMBL9613348 | 0.76 | ALDH1A1 (0.72) | HDAC1HDAC8HDAC6HPGDHPGDS | |
| SCHEMBL168519 | 0.75 | HTR2B (0.66) | HDAC1HDAC8HDAC6TDP1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846424-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2010-01-27 | — | — | EP | disclosed |