Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28144719 | 0.81 | CYP11B2 (0.43) | CYP11B2CYP11B1RAB9AMEN1KMT2A | |
| SCHEMBL13996075 | 0.79 | MEN1 (0.62) | CYP11B2CYP11B1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL23502438 | 0.77 | CTSS (0.52) | CTSK | |
| SCHEMBL27905437 | 0.77 | CHEK1 (0.43) | CYP11B2CYP11B1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13283433 | 0.76 | RAB9A (0.60) | CTSKRAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL12146378 | 0.75 | CYP1A2 (0.35) | CYP1A2CYP3A4FYN | |
| SCHEMBL18574185 | 0.75 | L3MBTL1 (0.43) | RAB9ASMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2614938 | 0.74 | RAB9A (0.47) | CYP11B2CYP11B1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL830961 | 0.73 | NOS3 (0.36) | — | |
| SCHEMBL19308315 | 0.73 | TP53 (0.43) | RAB9ASMN1; SMN2KMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846424-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2010-01-27 | — | — | EP | disclosed |