Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29165406 | 0.89 | AKT1 (0.48) | SIRT1AKT1SMN1; SMN2LMNATDP1 | |
| SCHEMBL231042 | 0.79 | SIRT1 (0.71) | SIRT1L3MBTL1SMN1; SMN2LMNATDP1 | |
| SCHEMBL8959187 | 0.79 | SIRT1 (0.71) | SIRT1L3MBTL1SMN1; SMN2LMNATDP1 | |
| SCHEMBL18813000 | 0.76 | SIRT1 (0.62) | SIRT1L3MBTL1SMN1; SMN2LMNATDP1 | |
| SCHEMBL10347642 | 0.76 | AKT1 (0.61) | AKT1SMN1; SMN2LMNATDP1MAPT | |
| SCHEMBL3075574 | 0.76 | SIRT1 (0.67) | SIRT1L3MBTL1SMN1; SMN2LMNATDP1 | |
| SCHEMBL11476180 | 0.76 | SIRT1 (0.67) | SIRT1L3MBTL1SMN1; SMN2LMNATDP1 | |
| SCHEMBL2417850 | 0.76 | SIRT1 (0.67) | SIRT1L3MBTL1SMN1; SMN2LMNATDP1 | |
| SCHEMBL1030659 | 0.76 | SIRT1 (1.00) | SIRT1L3MBTL1SMN1; SMN2LMNATDP1 | |
| SCHEMBL5887723 | 0.75 | SIRT1 (0.61) | SIRT1L3MBTL1LMNATDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937091-B2 | Inhibitor of protein crosslinking and use of the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2015-01-20 | — | — | US | disclosed |
| US-20120277423-A1 | PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME | JAPAN SCIENCE AND TECHNOLOGY AGENCY | 2012-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277423-A1 | PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME | ARGLU1, F12, CDKL1 | SIRT1 1142/4885AKT1 1984/4885L3MBTL1 1521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.