Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2129013 | 0.90 | SIRT1 (0.65) | SIRT1L3MBTL1MAPTTDP1POLB | |
| SCHEMBL18697239 | 0.89 | L3MBTL1 (0.61) | SIRT1L3MBTL1MAPTTDP1POLB | |
| SCHEMBL231042 | 0.87 | SIRT1 (0.71) | SIRT1L3MBTL1MAPTTDP1POLB | |
| SCHEMBL9625755 | 0.84 | SIRT1 (0.58) | SIRT1L3MBTL1MAPTTDP1POLB | |
| SCHEMBL11476180 | 0.83 | SIRT1 (0.67) | SIRT1L3MBTL1MAPTTDP1POLB | |
| SCHEMBL1030659 | 0.83 | SIRT1 (1.00) | SIRT1L3MBTL1MAPTTDP1POLB | |
| SCHEMBL2417850 | 0.83 | SIRT1 (0.67) | SIRT1L3MBTL1MAPTTDP1POLB | |
| SCHEMBL3075574 | 0.83 | SIRT1 (0.67) | SIRT1L3MBTL1MAPTTDP1POLB | |
| SCHEMBL9625444 | 0.83 | SIRT1 (0.56) | SIRT1L3MBTL1MAPTTDP1POLB | |
| SCHEMBL1127672 | 0.82 | SIRT1 (0.56) | SIRT1L3MBTL1MAPTTDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5194483-A | — | — | None | — | — | JP | disclosed |
| EP-0521823-B1 | Phenylthiophenyl ketones | CIBA GEIGY AG (CH) | 1996-01-17 | — | — | EP | disclosed |
| US-5290952-A | Phenylthiophenyl ketones | CIBA-GEIGY CORPORATION (US) | 1994-03-01 | — | — | US | disclosed |
| US-5290952-A | Phenylthiophenyl ketones | CIBA-GEIGY CORPORATION (US) | 1994-03-01 | — | — | US | disclosed |
| JP-H05194483-A | PHENYLTHIOPHENYL KETONE | CIBA GEIGY AG | 1993-08-03 | — | — | JP | disclosed |
| EP-0521823-A1 | Phenylthiophenyl ketones | CIBA-GEIGY AG (CH) | 1993-01-07 | — | — | EP | disclosed |