SCHEMBL1353027

SCHEMBL1353027

O=C(Cl)c1ccc(-c2cc(C(=O)Cl)ccc2-c2ccccc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 1/20 0.49
EGFR P00533 4/20 0.44
PTPN1 P18031 1/20 0.43
GSK3B P49841 1/20 0.43
MAPT P10636 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
ALDH1A1 P00352 1/20 0.42
TTR P02766 1/20 0.42
PTPRC P08575 2/20 0.41
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
CTDSP1 Q9GZU7 1/20 0.40
MAP4K4 O95819 1/20 0.40
SRD5A2 P31213 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
BACE1 P56817 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30876050 0.84 ALDH1A1 (0.43) PTGS2MAPTSMN1; SMN2ALDH1A1NPC1
Biphenyl SCHEMBL28809192 0.82 SMN1; SMN2 (0.60) EGFRPTPN1GSK3BMAPTSMN1; SMN2
SCHEMBL9452041 0.82 SMN1; SMN2 (0.60) EGFRPTPN1GSK3BMAPTSMN1; SMN2
SCHEMBL14416 0.82 SMN1; SMN2 (0.60) EGFRPTPN1GSK3BMAPTSMN1; SMN2
SCHEMBL8723556 0.82 SMN1; SMN2 (0.60) EGFRPTPN1GSK3BMAPTSMN1; SMN2
SCHEMBL9490431 0.81 BCAT2 (0.44) EGFRPTPN1MAPTSMN1; SMN2ALDH1A1
SCHEMBL8775411 0.81 HDAC7 (0.42) PTPN1MAPTSMN1; SMN2ALDH1A1TTR
SCHEMBL6207095 0.81 SRD5A2 (0.50) EGFRALDH1A1SRD5A2L3MBTL1
SCHEMBL3809545 0.81 TTR (0.58) PTGS2EGFRALDH1A1TTRPTPRC
SCHEMBL2213544 0.81 TTR (0.58) PTGS2EGFRALDH1A1TTRPTPRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8755022-B2 Liquid crystal display cell with fast response and continuous gray scale THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2014-06-17 US disclosed
US-20110285928-A1 Liquid crystal display cell with fast response and continuous gray scale THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2011-11-24 US disclosed
US-5393612-A Conductor and insulating coating having tensile strength of at least 13 kg/mm2 SUMITOMO ELECTRIC INDUSTRIES, LTD. (JP) 1995-02-28 US disclosed