Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | NPC1 | O15118 | 6/20 | 0.71 |
| ▸ | RAB9A | P51151 | 6/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.71 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 7/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | SCD | O00767 | 2/20 | 0.61 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1353349 | 0.91 | KDM4E (0.81) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL4916732 | 0.84 | NPC1 (0.74) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL6766057 | 0.84 | NPC1 (1.00) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL16742079 | 0.81 | KDM4E (0.83) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL16562119 | 0.80 | NPC1 (0.80) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL6769684 | 0.79 | NPC1 (1.00) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL1353585 | 0.78 | NPC1 (0.73) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL4919648 | 0.77 | L3MBTL1 (0.76) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL13568288 | 0.77 | NPC1 (0.82) | KDM4EL3MBTL1HTTNPC1RAB9A | |
| SCHEMBL16549373 | 0.77 | KDM4E (0.70) | KDM4EL3MBTL1HTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063046-B2 | Benzamide derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-11-22 | — | — | US | disclosed |
| US-8063046-B2 | Benzamide derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-11-22 | — | — | US | disclosed |
| US-8063046-B2 | Benzamide derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-11-22 | — | — | US | disclosed |
| EP-1698618-B1 | BENZAMIDE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2011-05-18 | — | — | EP | disclosed |
| US-20100179326-A1 | BENZAMIDE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-07-15 | — | — | US | disclosed |
| US-20100179326-A1 | BENZAMIDE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-07-15 | — | — | US | disclosed |
| US-20100179326-A1 | BENZAMIDE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-07-15 | — | — | US | disclosed |
| US-7705053-B2 | Benzamide derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-04-27 | — | — | US | disclosed |
| US-7705053-B2 | Benzamide derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-04-27 | — | — | US | disclosed |
| US-7705053-B2 | Benzamide derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2010-04-27 | — | — | US | disclosed |
| US-20070123493-A1 | Benzamide derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-05-31 | — | — | US | disclosed |
| US-20070123493-A1 | Benzamide derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-05-31 | — | — | US | disclosed |
| US-20070123493-A1 | Benzamide derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-05-31 | — | — | US | disclosed |
| EP-1698618-A1 | BENZAMIDE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-09-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123493-A1 | Benzamide derivative | BDKRB1, BDKRB2, NR1H2 | KDM4E 2503/4885L3MBTL1 1513/4885HTT 4531/4885 |
| US-20100179326-A1 | BENZAMIDE DERIVATIVE | NR0B2, NR1H2, CNR2 | KDM4E 2365/4885L3MBTL1 1036/4885HTT 4238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.