Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15383833 | 0.91 | SCN9A (0.52) | NOS3NOS1NOS2LOXL2SCN9A | |
| SCHEMBL18049349 | 0.82 | LOXL2 (0.62) | LOXL2SCN9AMEN1KMT2ANPC1 | |
| SCHEMBL2956020 | 0.82 | LOXL2 (0.43) | LOXL2SREBF2SCN9AMEN1KMT2A | |
| SCHEMBL4492835 | 0.82 | RECQL (0.47) | LOXL2SCN9AMEN1KMT2ANPC1 | |
| SCHEMBL4117407 | 0.82 | LOXL2 (0.43) | LOXL2SREBF2SCN9AMEN1KMT2A | |
| SCHEMBL27802351 | 0.82 | NOS3 (0.47) | NOS3NOS1NOS2LOXL2LMNA | |
| SCHEMBL10271516 | 0.81 | ASIC3 (0.53) | NOS3NOS1NOS2LOXL2SREBF2 | |
| SCHEMBL13532993 | 0.81 | SCN9A (0.41) | LOXL2SREBF2SCN9AMAPK14MEN1 | |
| SCHEMBL17981871 | 0.81 | LOXL2 (0.45) | LOXL2SREBF2SCN9AMEN1KMT2A | |
| SCHEMBL913143 | 0.80 | NOS3 (0.61) | NOS3NOS1NOS2LOXL2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101951909-B | Pyridopyrazinones derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes | MERCK PATENT GMBH | 2013-05-15 | — | — | CN | claimed |
| CN-101951909-A | As the pyrido-pyrazine ketones derivant of insulin secretion stimulant, the method that obtains them and the purposes in the treatment diabetes thereof | MERCK PATENT GMBH | 2011-01-19 | — | — | CN | claimed |
| CN-101951909-B | Pyridopyrazinones derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes | MERCK PATENT GMBH | 2013-05-15 | — | — | CN | disclosed |
| CN-101951909-A | As the pyrido-pyrazine ketones derivant of insulin secretion stimulant, the method that obtains them and the purposes in the treatment diabetes thereof | MERCK PATENT GMBH | 2011-01-19 | — | — | CN | disclosed |
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | BRAINCELLS, INC. (US) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009983-A1 | 5 HT RECEPTOR MEDIATED NEUROGENESIS | HTR6, GAP43, HTR5A | NOS3 400/4885NOS1 552/4885NOS2 399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.