Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16421193 | 0.87 | ALDH1A1 (0.49) | ALDH1A1TSHRSMN1; SMN2ALOX15MAPT | |
| SCHEMBL18763952 | 0.79 | NQO1 (0.50) | ALDH1A1TSHRSMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL21949349 | 0.79 | ALDH1A1 (0.44) | ALDH1A1TSHRALOX15PPARGPPARA | |
| SCHEMBL9314216 | 0.78 | SMN1; SMN2 (0.44) | ALDH1A1TSHRSMN1; SMN2ALOX15MAPT | |
| SCHEMBL18591898 | 0.76 | ALDH1A1 (0.45) | ALDH1A1TSHRSMN1; SMN2ALOX15PPARG | |
| SCHEMBL29416383 | 0.76 | ALOX15 (0.52) | ALDH1A1TSHRSMN1; SMN2ALOX15MAPT | |
| SCHEMBL2435587 | 0.76 | ALOX15 (0.52) | ALDH1A1TSHRSMN1; SMN2ALOX15MAPT | |
| SCHEMBL12612087 | 0.76 | LMNA (0.60) | ALDH1A1TSHRSMN1; SMN2ALOX15PPARG | |
| SCHEMBL18851549 | 0.75 | MCHR1 (0.43) | ALDH1A1ALOX15MAPT | |
| SCHEMBL10239026 | 0.75 | MCHR1 (0.35) | ALDH1A1ALOX15FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7649015-B2 | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2010-01-19 | — | — | US | disclosed |
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | GILEAD SCIENCES, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | PPA1, PNP, PPME1 | ALDH1A1 3337/4885TSHR 4782/4885SMN1; SMN2 3324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.