Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20747091 | 1.00 | RIPK1 (0.52) | RIPK1LMNAHSD11B1BCAT2KDM4E | |
| SCHEMBL13543291 | 1.00 | RIPK1 (0.52) | RIPK1LMNAHSD11B1BCAT2KDM4E | |
| SCHEMBL14519738 | 0.84 | LMNA (0.49) | RIPK1LMNAHSD11B1HPGDMAPT | |
| SCHEMBL6073420 | 0.79 | HSD11B1 (0.43) | HSD11B1SMN1; SMN2MAPT | |
| SCHEMBL11379648 | 0.79 | CES2 (0.44) | RIPK1LMNAHSD11B1KDM4EL3MBTL1 | |
| SCHEMBL14350508 | 0.78 | RIPK1 (0.53) | RIPK1LMNABCAT2KDM4EL3MBTL1 | |
| SCHEMBL9222957 | 0.78 | MAPT (0.64) | HSD11B1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL12338077 | 0.78 | LMNA (0.56) | RIPK1LMNABCAT2KDM4EL3MBTL1 | |
| SCHEMBL6441268 | 0.78 | LMNA (0.56) | RIPK1LMNABCAT2KDM4EL3MBTL1 | |
| SCHEMBL6991 | 0.78 | LMNA (0.56) | RIPK1LMNABCAT2KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |