Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8931495 | 0.82 | PTGS2 (0.59) | MAPTNPSR1PTGS2PTGS1GABRA5 | |
| SCHEMBL10262345 | 0.78 | GPBAR1 (0.51) | GPBAR1MAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL13118075 | 0.75 | ALDH1A1 (0.55) | GPBAR1MAPTTDP1L3MBTL1NPSR1 | |
| SCHEMBL820838 | 0.73 | PTGS1 (0.59) | GPBAR1MAPTALDH1A1PTGS2PTGS1 | |
| SCHEMBL5773713 | 0.72 | GABRA5 (0.50) | GPBAR1MAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL18557580 | 0.72 | GPBAR1 (0.47) | GPBAR1MAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL2928713 | 0.71 | GABRA5 (0.52) | GPBAR1GHSRGABRA5 | |
| SCHEMBL4300399 | 0.71 | ATM (0.54) | GPBAR1MAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL3951419 | 0.71 | GPBAR1 (0.46) | GPBAR1MAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL27525339 | 0.71 | GPBAR1 (0.49) | GPBAR1MAPTPOLBTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324133-B2 | Fungicide 2-pyridyl-methylene-carboxamide derivatives | BAYER CROPSCIENCE AG (DE) | 2012-12-04 | — | — | US | disclosed |
| US-8324133-B2 | Fungicide 2-pyridyl-methylene-carboxamide derivatives | BAYER CROPSCIENCE AG (DE) | 2012-12-04 | — | — | US | disclosed |
| US-20100010048-A1 | Fungicide 2-pyridyl-methylene-carboxamide derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
| US-20100010048-A1 | Fungicide 2-pyridyl-methylene-carboxamide derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010048-A1 | Fungicide 2-pyridyl-methylene-carboxamide derivatives | CYP51A1, ME2, ME3 | GPBAR1 4694/4885MAPT 2039/4885POLB 3219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.