Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AS3MT | Q9HBK9 | 6/20 | 0.35 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
| ▸ | PFKFB2 | O60825 | 4/20 | 0.32 |
| ▸ | PFKFB1 | P16118 | 4/20 | 0.32 |
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.32 |
| ▸ | NSD2 | O96028 | 2/20 | 0.32 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | BCL6 | P41182 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13362071 | 0.80 | MAPT (0.40) | GAAKDM4EMEN1KMT2ALMNA | |
| SCHEMBL1466312 | 0.79 | CFTR (0.47) | GAAKDM4EMEN1KMT2AAS3MT | |
| SCHEMBL19687578 | 0.69 | KDM1A (0.39) | GAAKDM4EMEN1KMT2AKDM1A | |
| SCHEMBL13547941 | 0.62 | PFKFB1 (0.39) | AS3MTPFKFB2PFKFB1PFKFB3NSD2 | |
| SCHEMBL14231572 | 0.62 | PGR (0.43) | AS3MTPFKFB2PFKFB1PFKFB3 | |
| SCHEMBL5857121 | 0.60 | AS3MT (0.56) | GAAKDM4EMEN1KMT2AAS3MT | |
| SCHEMBL15653075 | 0.59 | KDM4E (0.47) | GAAKDM4EMEN1KMT2ALMNA | |
| SCHEMBL2431507 | 0.58 | AR (0.63) | GAAKDM4EMEN1KMT2ALMNA | |
| SCHEMBL28058002 | 0.58 | GAA (0.59) | GAALMNAPOLBMAPTATM | |
| SCHEMBL2414244 | 0.58 | MMP2 (0.32) | GAAKDM4EMEN1KMT2AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645789-B2 | Indole derivatives as CFTR modulators | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-01-12 | — | — | US | disclosed |
| US-20090131492-A1 | Indole derivatives as CFTR modulators | VERTEX PHARMACEUTICALS INCORPORATED | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131492-A1 | Indole derivatives as CFTR modulators | CFTR, ABCB1, ABCB11 | GAA 1992/4885KDM4E 3861/4885MEN1 4672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.