Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.58 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.58 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.58 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.58 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.58 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.58 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.58 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.55 |
| ▸ | HNF4A | P41235 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.50 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.49 |
| ▸ | BAD | Q92934 | 1/20 | 0.49 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2291774 | 1.00 | GRIK1 (0.58) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL1019981 | 1.00 | GRIK1 (0.58) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL29542528 | 1.00 | GRIK1 (0.58) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| Hydrochloric Acid SCHEMBL26105180 | 0.98 | GRIK1 (0.56) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8902281 | 0.91 | ALDH1A1 (0.62) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL70202 | 0.91 | ALDH1A1 (0.62) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL70201 | 0.91 | ALDH1A1 (0.62) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL68552 | 0.89 | GRIK1 (0.56) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL68551 | 0.89 | GRIK1 (0.56) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL9798108 | 0.87 | TRPA1 (0.56) | GRIK1GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11858889-B2 | Compound for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease | THE TRUSTEES OF INDIANA UNIVERSITY (US) | 2024-01-02 | — | — | US | disclosed |
| CN-114713283-A | Cobalt nanoparticle efficient selective catalytic system and method for reducing alkyne to generate (Z) -olefin by using same | 沈阳药科大学 | 2022-07-08 | — | — | CN | disclosed |
| US-20220144795-A1 | COMPOUND FOR MODULATING DDAH AND ADMA LEVELS, AS WELL AS METHODS OF USING THEREOF TO TREAT DISEASE | UNIV INDIANA TRUSTEES (US) | 2022-05-12 | — | — | US | disclosed |
| US-20210009498-A1 | COMPOUND FOR MODULATING DDAH AND ADMA LEVELS, AS WELL AS METHODS OF USING THEREOF TO TREAT DISEASE | THE TRUSTEES OF INDIANA UNIVERSITY | 2021-01-14 | — | — | US | disclosed |
| US-10254562-B2 | Methods for tailoring the refractive index of lenses | BATTELLE MEMORIAL INSTITUTE (US) | 2019-04-09 | — | — | US | disclosed |
| US-9827088-B2 | Methods of altering the refractive index of materials | BATTELLE MEMORIAL INSTITUTE (US) | 2017-11-28 | — | — | US | disclosed |
| US-9421090-B2 | Adjustable intraocular lens | BATTELLE MEDICAL INSTITUTE (US) | 2016-08-23 | — | — | US | disclosed |
| US-20160229132-A1 | METHODS OF ALTERING OPTICAL POWER OF A LENS | BATTELLE MEMORIAL INSTITUTE | 2016-08-11 | — | — | US | disclosed |
| US-20160228238-A1 | METHODS OF ALTERING THE REFRACTIVE INDEX OF MATERIALS | BATTELLE MEMORIAL INSTITUTE | 2016-08-11 | — | — | US | disclosed |
| US-20160221283-A1 | METHODS FOR TAILORING THE REFRACTIVE INDEX OF LENSES | BATTELLE MEMORIAL INSTITUTE (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160195735-A1 | METHODS FOR TAILORING THE REFRACTIVE INDEX OF LENSES | BATTELLE MEMORIAL INSTITUTE | 2016-07-07 | — | — | US | disclosed |
| US-20160195734-A1 | METHODS OF ALTERING THE REFRACTIVE INDEX OF MATERIALS | BATTELLE MEMORIAL INSTITUTE | 2016-07-07 | — | — | US | disclosed |
| US-9232993-B2 | Adjustable intraocular lens | BATTELLE MEMORIAL INSTITUTE (US) | 2016-01-12 | — | — | US | disclosed |
| US-20120268710-A1 | ADJUSTABLE INTRAOCULAR LENS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11858889-B2 | Compound for modulating DDAH and ADMA levels, as well as methods of using thereof to treat disease | ADM2, DDAH1, BHMT | GRIK1 1928/4885GRIA1 1138/4885GRIA2 1492/4885 |
| US-20220144795-A1 | COMPOUND FOR MODULATING DDAH AND ADMA LEVELS, AS WELL AS METHODS OF USING THEREOF TO TREAT DISEASE | ADM2, DDAH1, BHMT | GRIK1 1928/4885GRIA1 1138/4885GRIA2 1492/4885 |
| US-20210009498-A1 | COMPOUND FOR MODULATING DDAH AND ADMA LEVELS, AS WELL AS METHODS OF USING THEREOF TO TREAT DISEASE | ADM2, DDAH1, BHMT | GRIK1 1928/4885GRIA1 1138/4885GRIA2 1492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.