Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Tetracaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A known ✓ | Q14524 | 2/20 | 0.97 |
| ▸ | SCN1A known ✓ | P35498 | 2/20 | 0.97 |
| ▸ | SCN2A known ✓ | Q99250 | 2/20 | 0.97 |
| ▸ | SCN3A known ✓ | Q9NY46 | 2/20 | 0.97 |
| ▸ | SCN7A known ✓ | Q01118 | 1/20 | 0.97 |
| ▸ | SCN9A known ✓ | Q15858 | 1/20 | 0.97 |
| ▸ | SCN8A known ✓ | Q9UQD0 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.97 |
| ▸ | DRD3 | P35462 | 2/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.97 |
| ▸ | MAOA | P21397 | 1/20 | 0.97 |
| ▸ | CNR1 | P21554 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetracaine SCHEMBL24370 | 1.00 | LMNA (1.00) | LMNABLMKDM4EGMNNRAB9A | |
| Tetracaine SCHEMBL34714 | 0.99 | LMNA (1.00) | LMNABLMKDM4EGMNNRAB9A | |
| Tetracaine SCHEMBL27896875 | 0.97 | LMNA (0.97) | LMNABLMKDM4EGMNNRAB9A | |
| Tetracaine SCHEMBL28641231 | 0.97 | LMNA (0.97) | LMNABLMKDM4EGMNNRAB9A | |
| Tetracaine SCHEMBL7774179 | 0.97 | LMNA (0.97) | LMNABLMKDM4EGMNNRAB9A | |
| Tetracaine SCHEMBL3176478 | 0.97 | LMNA (0.97) | LMNABLMKDM4EGMNNRAB9A | |
| Tetracaine SCHEMBL2728732 | 0.96 | LMNA (0.95) | LMNABLMKDM4EGMNNRAB9A | |
| Tetracaine SCHEMBL1652724 | 0.96 | LMNA (0.95) | LMNABLMKDM4EGMNNRAB9A | |
| Tetracaine SCHEMBL1840446 | 0.94 | LMNA (0.90) | LMNABLMKDM4EGMNNRAB9A | |
| SCHEMBL15412942 | 0.94 | LMNA (0.90) | LMNABLMKDM4EGMNNRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117298071-A | Oral cavity patch for treating dental ulcer and preparation method thereof | 力品药业(厦门)股份有限公司 | 2023-12-29 | — | — | CN | disclosed |
| EP-1660050-B1 | Ibuprofen-containing fast dissolving tablet | WYETH LLC (US) | 2016-11-23 | — | — | EP | disclosed |
| US-20140249190-A1 | Fast Dissolving Tablet | WYETH LLC (US) | 2014-09-04 | — | — | US | disclosed |
| US-20130296385-A1 | Fast Dissolving Tablet | WYETH LLC (US) | 2013-11-07 | — | — | US | disclosed |
| US-20110288135-A1 | Fast Dissolving Tablet | WYETH LLC (US) | 2011-11-24 | — | — | US | disclosed |
| EP-2353592-A1 | Therapeutic causing contraction of mucosal tissue and method of treating diseases relating to mucosal tissues | Japan Science and Technology Agency (JP) | 2011-08-10 | — | — | EP | disclosed |
| US-7799342-B2 | Which dissolve rapidly in the mouth and provide an excellent mouthfeel | WYETH LLC (US) | 2010-09-21 | — | — | US | disclosed |
| US-20100022492-A1 | THERAPEUTIC CAUSING CONTRACTION OF MUCOSAL TISSUE, METHOD OF TREATING DISEASES RELATING TO MUCOSAL TISSUES, INJECTOR AND THERAPEUTIC SET | WU, MEN-DAR (JP) | 2010-01-28 | — | — | US | disclosed |
| EP-1660050-A4 | FAST DISSOLVING TABLET | WYETH CORP (US) | 2008-09-03 | — | — | EP | disclosed |
| EP-1660050-A1 | FAST DISSOLVING TABLET | Wyeth (US) | 2006-05-31 | — | — | EP | disclosed |
| US-20050187303-A1 | Therapeutic causing contraction of mucosal tissue, method of treating diseases relating to mucosal tissues, injector and therapeutic set | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2005-08-25 | — | — | US | disclosed |
| EP-1557163-A1 | THERAPEUTIC CAUSING CONTRACTION OF MUCOSAL TISSUE, METHOD OF TREATING DISEASES RELATING TO MUCOSAL TISSUES, INJECTOR AND THERAPEUTIC SET | Japan Science and Technology Agency (JP) | 2005-07-27 | — | — | EP | disclosed |
| WO-2005018617-A1 | FAST DISSOLVING TABLET | WYETH (US) | 2005-03-03 | — | — | WO | disclosed |
| US-20040037878-A1 | Which dissolve rapidly in the mouth and provide an excellent mouthfeel | WYETH | 2004-02-26 | — | — | US | disclosed |