Tetracaine

Tetracaine

SCHEMBL34714

CCCCNc1ccc(C(=O)OCCN(C)C)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A

The experimentally established mechanism targets of Tetracaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN5A known ✓ Q14524 2/20 1.00
SCN1A known ✓ P35498 2/20 1.00
SCN2A known ✓ Q99250 2/20 1.00
SCN3A known ✓ Q9NY46 2/20 1.00
SCN7A known ✓ Q01118 1/20 1.00
SCN9A known ✓ Q15858 1/20 1.00
SCN8A known ✓ Q9UQD0 1/20 1.00
LMNA P02545 5/20 1.00
CYP1A2 P05177 4/20 1.00
MAPK1 P28482 2/20 1.00
DRD3 P35462 2/20 1.00
SLC6A3 Q01959 2/20 1.00
KCNH2 Q12809 2/20 1.00
MAOA P21397 1/20 1.00
CNR1 P21554 1/20 1.00
DRD4 P21917 1/20 1.00
ACHE P22303 1/20 1.00
HRH2 P25021 1/20 1.00
HTR2A P28223 1/20 1.00
HTR2C P28335 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetracaine SCHEMBL24370 0.99 LMNA (1.00) LMNACYP1A2SCN5AMAPK1DRD3
Tetracaine SCHEMBL28641231 0.99 LMNA (0.97) LMNACYP1A2SCN5AMAPK1DRD3
Tetracaine SCHEMBL3176478 0.99 LMNA (0.97) LMNACYP1A2SCN5AMAPK1DRD3
Tetracaine SCHEMBL7774179 0.99 LMNA (0.97) LMNACYP1A2SCN5AMAPK1DRD3
Tetracaine SCHEMBL1355595 0.99 LMNA (1.00) LMNACYP1A2SCN5AMAPK1DRD3
Tetracaine SCHEMBL27896875 0.99 LMNA (0.97) LMNACYP1A2SCN5AMAPK1DRD3
Tetracaine SCHEMBL2728732 0.97 LMNA (0.95) LMNACYP1A2SCN5AMAPK1DRD3
Tetracaine SCHEMBL1652724 0.97 LMNA (0.95) LMNACYP1A2SCN5AMAPK1DRD3
Tetracaine SCHEMBL1840446 0.95 LMNA (0.90) LMNACYP1A2SCN5AMAPK1DRD3
SCHEMBL15412942 0.95 LMNA (0.90) LMNACYP1A2SCN5AMAPK1DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 47696 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144801-A1 COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING MUSCLE CONDITIONS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2026-05-28 US claimed
WO-2026106456-A1 ASSISTANCE AND RESISTANCE DEVICE FOR PERFORMING PRESS-UP EXERCISES BELTRAN RAMIREZ JESUS RAUL (MX) 2026-05-21 WO claimed
US-20260137650-A1 MODULATORS OF RAR RELATED ORPHAN RECEPTORS (RORs) 11949098 CANADA INC (CA) 2026-05-21 US claimed
US-20260137637-A1 ANESTHETIC AGENT MICRO AND NANO PARTICLES, AND METHODS OF MAKING AND USING THE SAME HAAS ERIC (US) 2026-05-21 US claimed
US-20260137558-A1 OPHTHALMIC DEVICE Able Tx Ltd. (IL) 2026-05-21 US claimed
EP-4743122-A1 THERAPEUTIC SEALANTS BASED UPON DRUG CONJUGATES The Johns Hopkins University (US) 2026-05-20 EP claimed
CN-122031371-A Oral hydrogel surface-tingling patch and preparation method thereof 深圳市儿童医院 2026-05-15 CN claimed
CN-122031290-A Percutaneous permeation promoting system and preparation method and application thereof 北京工商大学 2026-05-15 CN claimed
EP-4741492-A2 NECROSIS INHIBITOR Linkgevity Limited (GB) 2026-05-13 EP claimed
CN-122005922-A Porous polyester microsphere filler for improving external nose volume and morphology 常州药物研究所有限公司 2026-05-12 CN claimed
EP-0002426-A1 Antiperspirant Playtex-Wallco Aktiebolag (SE) 1979-06-13 EP claimed
EP-0002425-A1 Local anesthetic mixture for topical application, and process for its preparation Astra Läkemedel Aktiebolag (SE) 1979-06-13 EP claimed
US-4148917-A PENETRATION THE PROCTER & GAMBLE COMPANY (US) 1979-04-10 US claimed
US-4091090-A PENETRANT ACCELERATOR COMPRISING CYCLOHEXYL-SUBSTITUTED ALKANOLS JOHNSON & JOHNSON (US) 1978-05-23 US claimed
US-4066747-A Polymeric orthoesters housing beneficial drug for controlled release therefrom ALZA CORPORATION (US) 1978-01-03 US claimed
US-4041174-A INJECTING AN ESTER LOCAL ANESTHETIC ROM-AMER PHARMACEUTICALS, LTD. (US) 1977-08-09 US claimed
US-4029794-A SAXITOXIN ASTRA PHARMACEUTICAL PRODUCTS, INC. (US) 1977-06-14 US claimed
US-4022899-A TETRODOXIN, DESOXYTETRODOXIN, AMINOALKYL BENZOATE ASTRA PHARMACEUTICAL PRODUCTS, INC. (US) 1977-05-10 US claimed
US-3978201-A BASE FOR OPHTHALMOLOGICAL MEDICINAL PREPARATION ON OPTHALMOLOGICAL MEDICINAL FILM KHROMOV GENNADY LVOVICH 1976-08-31 US claimed
US-3935303-A Base for ophthalmological medicinal preparations and on ophthalmological medicinal film KHROMOV GENNADY LVOVICH 1976-01-27 US claimed