Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.90 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.90 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.90 |
| ▸ | MAOA | P21397 | 1/20 | 0.90 |
| ▸ | CNR1 | P21554 | 1/20 | 0.90 |
| ▸ | DRD4 | P21917 | 1/20 | 0.90 |
| ▸ | ACHE | P22303 | 1/20 | 0.90 |
| ▸ | HRH2 | P25021 | 1/20 | 0.90 |
| ▸ | HTR2A | P28223 | 1/20 | 0.90 |
| ▸ | HTR2C | P28335 | 1/20 | 0.90 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.90 |
| ▸ | HRH1 | P35367 | 1/20 | 0.90 |
| ▸ | DRD3 | P35462 | 1/20 | 0.90 |
| ▸ | SCN1A | P35498 | 1/20 | 0.90 |
| ▸ | HTR2B | P41595 | 1/20 | 0.90 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.90 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.90 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.90 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetracaine SCHEMBL34714 | 0.95 | LMNA (1.00) | LMNASCN5ACYP1A2MAPK1MAOA | |
| Tetracaine SCHEMBL1355595 | 0.94 | LMNA (1.00) | LMNASCN5ACYP1A2MAPK1MAOA | |
| Tetracaine SCHEMBL3176478 | 0.94 | LMNA (0.97) | LMNASCN5ACYP1A2MAPK1MAOA | |
| Tetracaine SCHEMBL7774179 | 0.94 | LMNA (0.97) | LMNASCN5ACYP1A2MAPK1MAOA | |
| Tetracaine SCHEMBL27896875 | 0.94 | LMNA (0.97) | LMNASCN5ACYP1A2MAPK1MAOA | |
| Tetracaine SCHEMBL28641231 | 0.94 | LMNA (0.97) | LMNASCN5ACYP1A2MAPK1MAOA | |
| Tetracaine SCHEMBL24370 | 0.94 | LMNA (1.00) | LMNASCN5ACYP1A2MAPK1MAOA | |
| Tetracaine SCHEMBL1652724 | 0.92 | LMNA (0.95) | LMNASCN5ACYP1A2MAPK1MAOA | |
| Tetracaine SCHEMBL2728732 | 0.92 | LMNA (0.95) | LMNASCN5ACYP1A2MAPK1MAOA | |
| Tetracaine SCHEMBL1840446 | 0.90 | LMNA (0.90) | LMNASCN5ACYP1A2MAPK1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458102-B2 | Derivatives of tetracaine | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-10-04 | — | — | US | disclosed |
| US-9458102-B2 | Derivatives of tetracaine | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-10-04 | — | — | US | disclosed |
| US-9458102-B2 | Derivatives of tetracaine | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2016-10-04 | — | — | US | disclosed |
| US-20140018422-A1 | DERIVATIVES OF TETRACAINE | WILLAMETTE UNIVERSITY (US) | 2014-01-16 | — | — | US | disclosed |
| US-20140018422-A1 | DERIVATIVES OF TETRACAINE | WILLAMETTE UNIVERSITY (US) | 2014-01-16 | — | — | US | disclosed |
| US-20140018422-A1 | DERIVATIVES OF TETRACAINE | WILLAMETTE UNIVERSITY (US) | 2014-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140018422-A1 | DERIVATIVES OF TETRACAINE | CACNA1G, CACNA1H, CACNA1I | LMNA 3105/4885SCN5A 137/4885CYP1A2 4272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.