Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Tetracaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A known ✓ | Q14524 | 2/20 | 0.97 |
| ▸ | SCN1A known ✓ | P35498 | 2/20 | 0.97 |
| ▸ | SCN2A known ✓ | Q99250 | 2/20 | 0.97 |
| ▸ | SCN3A known ✓ | Q9NY46 | 2/20 | 0.97 |
| ▸ | SCN7A known ✓ | Q01118 | 1/20 | 0.97 |
| ▸ | SCN9A known ✓ | Q15858 | 1/20 | 0.97 |
| ▸ | SCN8A known ✓ | Q9UQD0 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 5/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.97 |
| ▸ | DRD3 | P35462 | 2/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.97 |
| ▸ | MAOA | P21397 | 1/20 | 0.97 |
| ▸ | CNR1 | P21554 | 1/20 | 0.97 |
| ▸ | DRD4 | P21917 | 1/20 | 0.97 |
| ▸ | ACHE | P22303 | 1/20 | 0.97 |
| ▸ | HRH2 | P25021 | 1/20 | 0.97 |
| ▸ | HTR2A | P28223 | 1/20 | 0.97 |
| ▸ | HTR2C | P28335 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetracaine SCHEMBL34714 | 0.99 | LMNA (1.00) | LMNACYP1A2SCN5AMAPK1DRD3 | |
| Tetracaine SCHEMBL28641231 | 0.97 | LMNA (0.97) | LMNACYP1A2SCN5AMAPK1DRD3 | |
| Tetracaine SCHEMBL3176478 | 0.97 | LMNA (0.97) | LMNACYP1A2SCN5AMAPK1DRD3 | |
| Tetracaine SCHEMBL24370 | 0.97 | LMNA (1.00) | LMNACYP1A2SCN5AMAPK1DRD3 | |
| Tetracaine SCHEMBL1355595 | 0.97 | LMNA (1.00) | LMNACYP1A2SCN5AMAPK1DRD3 | |
| Tetracaine SCHEMBL27896875 | 0.97 | LMNA (0.97) | LMNACYP1A2SCN5AMAPK1DRD3 | |
| Tetracaine SCHEMBL1652724 | 0.96 | LMNA (0.95) | LMNACYP1A2SCN5AMAPK1DRD3 | |
| Tetracaine SCHEMBL2728732 | 0.96 | LMNA (0.95) | LMNACYP1A2SCN5AMAPK1DRD3 | |
| Tetracaine SCHEMBL1840446 | 0.94 | LMNA (0.90) | LMNACYP1A2SCN5AMAPK1DRD3 | |
| SCHEMBL15412942 | 0.94 | LMNA (0.90) | LMNACYP1A2SCN5AMAPK1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0522122-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING AMETHOCAINE | SMITH & NEPHEW (GB) | 2001-08-22 | — | — | EP | disclosed |
| US-5733930-A | TOPICAL GEL; ANAESTHESIA | T J SMITH & NEPHEW LIMITED (GB) | 1998-03-31 | — | — | US | disclosed |
| US-5580901-A | PERCUTANEOUS ANESTHETICS | T. J. SMITH & NEWPHEW LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0522122-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING AMETHOCAINE | T J Smith & Nephew Limited (GB) | 1993-01-13 | — | — | EP | disclosed |
| WO-1992013533-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING AMETHOCAINE | SMITH & NEPHEW PLC (GB) | 1992-08-20 | — | — | WO | disclosed |