Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | SCARB1 | Q8WTV0 | 4/20 | 0.32 |
| ▸ | KRAS | P01116 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13563240 | 0.87 | HTR6 (0.53) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL13563257 | 0.81 | HTR6 (0.46) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL14217957 | 0.76 | HTR6 (0.52) | HTR6CA1CA2 | |
| SCHEMBL13478801 | 0.73 | HTR6 (0.55) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL13626290 | 0.73 | HTR6 (0.54) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL13563274 | 0.72 | HTR6 (0.57) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL14218039 | 0.69 | HTR6 (0.43) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL13563338 | 0.68 | HTR6 (0.53) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL14218046 | 0.68 | HTR6 (0.47) | HTR6CA1CA2PTGS1PTGS2 | |
| SCHEMBL14624291 | 0.67 | HTR6 (0.59) | HTR6CA1CA2PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297100-B1 | TETRAHYDROCYCLOPENTA[B]INDOLE ANDROGEN RECEPTOR MODULATORS | LILLY CO ELI (US) | 2012-10-31 | — | — | EP | disclosed |
| WO-2009140448-A1 | TETRAHYDROCYCLOPENTA[B]INDOLE ANDROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2009-11-19 | — | — | WO | disclosed |