Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12846928 | 0.88 | KDM4E (0.41) | KDM4EHSD17B10LMNAHTTTSHR | |
| SCHEMBL12846921 | 0.79 | KDM4E (0.39) | KDM4EHSD17B10LMNAHTTPOLB | |
| SCHEMBL12846924 | 0.76 | KDM4E (0.37) | KDM4EHSD17B10LMNAHTTPOLB | |
| SCHEMBL12788663 | 0.75 | ALDH1A1 (0.48) | KDM4EHSD17B10LMNAPOLBALDH1A1 | |
| SCHEMBL12846922 | 0.74 | MEN1 (0.39) | KDM4EHSD17B10TSHRPOLBALDH1A1 | |
| SCHEMBL12789552 | 0.74 | KDM4E (0.46) | KDM4EHSD17B10LMNAPOLBALDH1A1 | |
| SCHEMBL12788398 | 0.73 | LMNA (0.45) | KDM4EHSD17B10LMNATSHRPOLB | |
| SCHEMBL12788750 | 0.73 | CTSD (0.41) | KDM4EHSD17B10LMNAPOLBALDH1A1 | |
| SCHEMBL12847303 | 0.72 | BRD4 (0.37) | KDM4EALDH1A1CYP1A2SMN1; SMN2MEN1 | |
| SCHEMBL12788497 | 0.71 | SMN1; SMN2 (0.51) | KDM4ELMNATSHRPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297117-B1 | BICYCLIC HETEROCYCLE DERIVATIVES AND USE THEREOF AS GPR119 MODULATORS | MERCK SHARP & DOHME (US) | 2012-10-31 | — | — | EP | disclosed |