Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | GSTK1 | Q9Y2Q3 | 2/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL28437633 | 0.92 | CAMK2A (0.38) | CAMK2AALDH1A1LMNAGPR84FFAR1 | |
| Bicarbonate SCHEMBL10850855 | 0.92 | LMNA (0.42) | CAMK2AALDH1A1LMNAGPR84FFAR1 | |
| Carbamic Acid SCHEMBL1073227 | 0.90 | CAMK2A (0.36) | CAMK2AALDH1A1LMNAGPR84FFAR1 | |
| Bicarbonate SCHEMBL10848259 | 0.90 | LMNA (0.46) | CAMK2AALDH1A1LMNAGPR84FFAR1 | |
| Glycolic Acid SCHEMBL11515132 | 0.90 | CAMK2A (0.42) | CAMK2AALDH1A1LMNAGPR84FFAR1 | |
| Acetic Acid SCHEMBL540581 | 0.90 | ALDH1A1 (0.41) | CAMK2AALDH1A1LMNAGPR84FFAR1 | |
| Acetic Acid SCHEMBL3683183 | 0.90 | ALDH1A1 (0.41) | CAMK2AALDH1A1LMNAGPR84FFAR1 | |
| SCHEMBL15027 | 0.88 | — | — | |
| Succinic Acid SCHEMBL542104 | 0.87 | CAMK2A (0.52) | CAMK2ALMNAGPR84FFAR1FFAR4 | |
| Malonic Acid SCHEMBL28252452 | 0.87 | LDHA (0.43) | CAMK2AALDH1A1LMNAGPR84FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303770-A1 | POLYOL COMPOUNDS AND ADHESIVE COMPOSITIONS PREPARED WITH THE SAME | ARKEMA FRANCE (FR) | 2023-09-28 | — | — | US | claimed |
| EP-4182371-A1 | POLYOL COMPOUNDS AND ADHESIVE COMPOSITIONS PREPARED WITH SAME | Dow Global Technologies LLC (US) | 2023-05-24 | — | — | EP | claimed |
| CN-116034146-A | Polyol compounds and adhesive compositions prepared therewith | 陶氏环球技术有限责任公司 | 2023-04-28 | — | — | CN | claimed |
| EP-4065622-A1 | FOAMED POLYURETHANE COMPOSITIONS | Presidium USA, Inc. (US) | 2022-10-05 | — | — | EP | claimed |
| CN-115023455-A | Foamed polyurethane composition | 美国主席团有限公司 | 2022-09-06 | — | — | CN | claimed |
| WO-2022011544-A1 | POLYOL COMPOUNDS AND ADHESIVE COMPOSITIONS PREPARED WITH SAME | DOW GLOBAL TECHNOLOGIES LLC (US) | 2022-01-20 | — | — | WO | claimed |
| WO-2021108289-A1 | FOAMED POLYURETHANE COMPOSITIONS | PRESIDIUM USA, INC. (US) | 2021-06-03 | — | — | WO | claimed |
| US-7635742-B2 | Crosslinking polyurethanes | RHODIA CHIMIE (FR) | 2009-12-22 | — | — | US | claimed |
| EP-1129120-B1 | MODIFIED POLYISOCYANATES | RHODIA CHIMIE SA (FR) | 2003-12-10 | — | — | EP | claimed |
| US-6180747-B1 | POLYESTERETHER COPOLYMERS | XEROX CORPORATION | 2001-01-30 | — | — | US | claimed |
| EP-0665260-B1 | Curable resin composition | NIPPON PAINT CO LTD (JP) | 1997-12-29 | — | — | EP | claimed |
| US-5466754-A | Cyclic alkylene carbonate groups, polyol, acid catalyst | NIPPON PAINT CO., LTD. (JP) | 1995-11-14 | — | — | US | claimed |
| EP-0665260-A2 | Curable resin composition | Nippon Paint Co., Ltd. (JP) | 1995-08-02 | — | — | EP | claimed |
| EP-2859027-B1 | RESINS BEARING CYCLIC CARBONATE GROUPS AND CROSS-LINKABLE COMPOSITIONS OF SAID RESINS HAVING A LOW VOC LEVEL | ARKEMA FRANCE (FR) | 2024-08-14 | — | — | EP | disclosed |
| US-20230303770-A1 | POLYOL COMPOUNDS AND ADHESIVE COMPOSITIONS PREPARED WITH THE SAME | ARKEMA FRANCE (FR) | 2023-09-28 | — | — | US | disclosed |
| WO-2023149827-A1 | PROCESS FOR PRODUCTION OF DI-TRIMETHYLOLPROPANE OXETANE | PERSTORP AB (SE) | 2023-08-10 | — | — | WO | disclosed |
| US-20040073046-A1 | Modified isocyanates | RHODIA CHIMIE (FR) | 2004-04-15 | — | — | US | disclosed |
| US-20030050424-A1 | Modified isocyanates | RHODIA CHIMIE (FR) | 2003-03-13 | — | — | US | disclosed |
| US-6291122-B1 | TONER WITH BRANCHED POLYESTER AND COLOR BISPHENYLENE. | XEROX CORPORATION | 2001-09-18 | — | — | US | disclosed |
| US-6180747-B1 | POLYESTERETHER COPOLYMERS | XEROX CORPORATION | 2001-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303770-A1 | POLYOL COMPOUNDS AND ADHESIVE COMPOSITIONS PREPARED WITH THE SAME | CDH1, PUF60, ICAM1 | CAMK2A 3822/4885ALDH1A1 1851/4885LMNA 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.