Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12549643 | 0.91 | TP53 (0.59) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL16010683 | 0.80 | KDM4E (0.52) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL14960024 | 0.74 | ALDH1A1 (0.64) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL12571746 | 0.73 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL15462269 | 0.72 | TNKS (0.61) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL12549588 | 0.72 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL13091023 | 0.66 | MAPT (0.64) | ALDH1A1HPGDTP53POLB | |
| SCHEMBL20989088 | 0.65 | ALDH1A1 (0.65) | ALDH1A1TP53POLBHDAC1HDAC11 | |
| SCHEMBL13574158 | 0.62 | HPGD (0.53) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL24247606 | 0.62 | HDAC6 (0.54) | HDAC1HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155001-A2 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-12-23 | — | — | WO | disclosed |