Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | TNKS | O95271 | 3/20 | 0.50 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12549503 | 0.93 | TNKS (0.59) | HPGDPOLBALDH1A1TSHRTNKS | |
| SCHEMBL15462269 | 0.79 | TNKS (0.61) | HPGDPOLBALDH1A1TNKSTNKS2 | |
| SCHEMBL16010683 | 0.70 | KDM4E (0.52) | HPGDPOLBALDH1A1TNKSTNKS2 | |
| SCHEMBL3869028 | 0.69 | TNKS (0.67) | HPGDPOLBTNKSTNKS2KDM4E | |
| SCHEMBL12549629 | 0.67 | TNKS (1.00) | HPGDPOLBALDH1A1TNKSTNKS2 | |
| SCHEMBL6520182 | 0.64 | POLB (0.69) | HPGDPOLBTNKSTNKS2KDM4E | |
| SCHEMBL21457876 | 0.64 | PKM (0.56) | HPGDPOLBALDH1A1KDM4ELMNA | |
| SCHEMBL12791230 | 0.63 | LMNA (0.72) | HPGDPOLBTNKSTNKS2KDM4E | |
| SCHEMBL16092741 | 0.62 | PGR (0.55) | ALDH1A1TSHRTNKSTNKS2KDM4E | |
| SCHEMBL13574150 | 0.62 | KDM4E (0.49) | HPGDPOLBALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155001-A2 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-12-23 | — | — | WO | disclosed |