Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13574150 | 0.91 | KDM4E (0.49) | TP53THRBKDM4EALDH1A1HPGD | |
| SCHEMBL16010683 | 0.82 | KDM4E (0.52) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL14960024 | 0.75 | ALDH1A1 (0.64) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL15462269 | 0.75 | TNKS (0.61) | TP53KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL12549588 | 0.73 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL13091023 | 0.72 | MAPT (0.64) | TP53ALDH1A1HPGDPOLBNPC1 | |
| SCHEMBL24031073 | 0.68 | HDAC6 (1.00) | TP53THRBHDAC1HDAC11HDAC8 | |
| SCHEMBL20989088 | 0.67 | ALDH1A1 (0.65) | TP53ALDH1A1HDAC1HDAC11HDAC8 | |
| SCHEMBL24031096 | 0.67 | HDAC1 (0.76) | TP53THRBHDAC1HDAC11HDAC8 | |
| SCHEMBL6522779 | 0.67 | TP53 (0.89) | TP53THRBALDH1A1HDAC1HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150374696-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-12-31 | — | — | US | disclosed |
| US-20150374696-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-12-31 | — | — | US | disclosed |
| US-9045416-B2 | WNT protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-06-02 | — | — | US | disclosed |
| US-9045416-B2 | WNT protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-06-02 | — | — | US | disclosed |
| US-20140038922-A1 | WNT PROTEIN SIGNALLING INHIBITORS | UNIV TEXAS (US) | 2014-02-06 | — | — | US | disclosed |
| US-20140038922-A1 | WNT PROTEIN SIGNALLING INHIBITORS | UNIV TEXAS (US) | 2014-02-06 | — | — | US | disclosed |
| US-8445491-B2 | Wnt protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-21 | — | — | US | disclosed |
| US-8445491-B2 | Wnt protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-21 | — | — | US | disclosed |
| US-20110136813-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2011-06-09 | — | — | US | disclosed |
| US-20110136813-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038922-A1 | WNT PROTEIN SIGNALLING INHIBITORS | WNT1, WNT3A, DKK1 | TP53 548/4885THRB 2008/4885KDM4E 4000/4885 |
| US-20110136813-A1 | WNT PROTEIN SIGNALLING INHIBITORS | WNT1, WNT3A, DKK1 | TP53 548/4885THRB 2008/4885KDM4E 4000/4885 |
| US-20150374696-A1 | WNT PROTEIN SIGNALLING INHIBITORS | WNT1, WNT3A, DKK1 | TP53 548/4885THRB 2008/4885KDM4E 4000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.