Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.61 |
| ▸ | HPGD | P15428 | 8/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14960024 | 0.88 | ALDH1A1 (0.64) | ALDH1A1HPGDKDM4EPOLBHSD17B10 | |
| SCHEMBL12571746 | 0.86 | ALDH1A1 (0.62) | ALDH1A1HPGDKDM4EPOLBHSD17B10 | |
| SCHEMBL26853240 | 0.73 | PKM (0.52) | KDM4EHSD17B10PKMGRIN1GRIN2A | |
| SCHEMBL16010683 | 0.73 | KDM4E (0.52) | ALDH1A1HPGDKDM4EPOLBHSD17B10 | |
| SCHEMBL15462269 | 0.73 | TNKS (0.61) | ALDH1A1HPGDKDM4EPOLBHSD17B10 | |
| SCHEMBL12549643 | 0.73 | TP53 (0.59) | ALDH1A1HPGDKDM4EPOLBHSD17B10 | |
| SCHEMBL13574150 | 0.72 | KDM4E (0.49) | ALDH1A1HPGDKDM4EPOLBHSD17B10 | |
| SCHEMBL12933335 | 0.71 | PGR (0.57) | ALDH1A1KDM4EHSD17B10SMN1; SMN2MAPK1 | |
| SCHEMBL13151057 | 0.69 | PKM (0.56) | KDM4EPOLBHSD17B10PKMGRIN1 | |
| SCHEMBL12933342 | 0.68 | P2RX4 (0.62) | POLBSMN1; SMN2MAPK1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150374696-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-12-31 | — | — | US | disclosed |
| US-9045416-B2 | WNT protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-06-02 | — | — | US | disclosed |
| US-20140038922-A1 | WNT PROTEIN SIGNALLING INHIBITORS | UNIV TEXAS (US) | 2014-02-06 | — | — | US | disclosed |
| US-8445491-B2 | Wnt protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-21 | — | — | US | disclosed |
| US-20110136813-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038922-A1 | WNT PROTEIN SIGNALLING INHIBITORS | WNT1, WNT3A, DKK1 | ALDH1A1 4690/4885HPGD 2617/4885KDM4E 4000/4885 |
| US-20110136813-A1 | WNT PROTEIN SIGNALLING INHIBITORS | WNT1, WNT3A, DKK1 | ALDH1A1 4690/4885HPGD 2617/4885KDM4E 4000/4885 |
| US-20150374696-A1 | WNT PROTEIN SIGNALLING INHIBITORS | WNT1, WNT3A, DKK1 | ALDH1A1 4690/4885HPGD 2617/4885KDM4E 4000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.