Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1357683 | 1.00 | ALDH1A1 (0.38) | ALDH1A1MAPTKDM4ENAMPTHDAC1 | |
| SCHEMBL12136107 | 0.94 | MAPT (0.41) | ALDH1A1MAPTKDM4ENAMPTPTGER2 | |
| Fumaric Acid SCHEMBL1357678 | 0.82 | HTR6 (0.42) | ALDH1A1HDAC1HTR6KLKB1 | |
| Fumaric Acid SCHEMBL1357673 | 0.82 | HTR6 (0.42) | ALDH1A1HDAC1HTR6KLKB1 | |
| Fumaric Acid SCHEMBL1278294 | 0.81 | EPHX2 (0.40) | ALDH1A1KDM4ENAMPTHDAC1TSHR | |
| Fumaric Acid SCHEMBL1278291 | 0.81 | EPHX2 (0.40) | ALDH1A1KDM4ENAMPTHDAC1TSHR | |
| Fumaric Acid SCHEMBL1355977 | 0.80 | SMN1; SMN2 (0.36) | ALDH1A1MAPTHDAC1TSHRKMT2A | |
| Fumaric Acid SCHEMBL1355982 | 0.80 | SMN1; SMN2 (0.36) | ALDH1A1MAPTHDAC1TSHRKMT2A | |
| SCHEMBL9611276 | 0.80 | HTR6 (0.38) | ALDH1A1MAPTKDM4EHTR6 | |
| Fumaric Acid SCHEMBL1357695 | 0.79 | RAB9A (0.39) | ALDH1A1MAPTTSHRKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2005957-B1 | ACID SECRETION INHIBITOR | TAKEDA PHARMACEUTICAL (JP) | 2012-05-30 | — | — | EP | disclosed |
| US-20110288040-A1 | ARYL- OR HETEROARYL-SULFONYL COMPOUNDS AS ACID SECRETION INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | US | disclosed |
| US-7994205-B2 | Aryl-or heteroaryl-sulfonyl compounds as acid secretion inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-08-09 | — | — | US | disclosed |
| US-20090118335-A1 | Acid Secretion Inhibitor | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-05-07 | — | — | US | disclosed |
| EP-2005957-A1 | ACID SECRETION INHIBITOR | Takeda Pharmaceutical Company Limited (JP) | 2008-12-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118335-A1 | Acid Secretion Inhibitor | ATP6AP1, HRH2, ATP6V1G1 | KMT2A 4237/4885ALDH1A1 1627/4885MAPT 4675/4885 |
| US-20110288040-A1 | ARYL- OR HETEROARYL-SULFONYL COMPOUNDS AS ACID SECRETION INHIBITORS | GHSR, GIPR, HRH2 | KMT2A 3735/4885ALDH1A1 1926/4885MAPT 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.