Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.57 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.55 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596041 | 0.85 | MAOB (0.67) | ALDH1A1SMN1; SMN2NR4A2MAOBSRD5A2 | |
| SCHEMBL3828084 | 0.84 | NPC1 (0.55) | MAPTALDH1A1NPC1SPHK2SPHK1 | |
| SCHEMBL13596039 | 0.83 | NR4A2 (0.52) | ALDH1A1SPHK2SPHK1SMPD1SMN1; SMN2 | |
| SCHEMBL3829972 | 0.82 | ALDH1A1 (0.51) | MAPTALDH1A1NPC1SPHK2SPHK1 | |
| SCHEMBL7410475 | 0.82 | SMPD1 (0.78) | MAPTALDH1A1NPC1SMPD1RAB9A | |
| SCHEMBL13596118 | 0.80 | MAOB (0.62) | MAPTRAB9ASMN1; SMN2NR4A2MAOB | |
| SCHEMBL863916 | 0.80 | ALDH1A1 (0.88) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1563616 | 0.79 | NR4A2 (0.50) | ALDH1A1SPHK2SPHK1SMPD1SMN1; SMN2 | |
| SCHEMBL13596052 | 0.78 | SMPD1 (0.50) | NPC1SMPD1RAB9ASMN1; SMN2NR4A2 | |
| SCHEMBL1564073 | 0.76 | FFAR1 (0.56) | SPHK2SPHK1SMPD1SMN1; SMN2NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318389-A1 | AGONISTS OF THE SPHINGOSINE-1 PHOSPHATE RECEPTOR | PRAECIS PHARMACEUTICALS INCORPORATED (US) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318389-A1 | AGONISTS OF THE SPHINGOSINE-1 PHOSPHATE RECEPTOR | S1PR1, S1PR3, S1PR5 | MAPT 4479/4885ALDH1A1 2888/4885NPC1 1484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.