SCHEMBL822875

SCHEMBL822875

N#Cc1ccc(Cn2cnc3c(N)nc(Cl)nc32)cc1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PDE8A O60658 10/20 0.56
YTHDC1 Q96MU7 5/20 0.55
PDE4A P27815 1/20 0.48
PDE4B Q07343 1/20 0.48
PDE4C Q08493 1/20 0.48
PDE4D Q08499 1/20 0.48
CDK1 P06493 1/20 0.47
NSD2 O96028 1/20 0.46
NSD3 Q9BZ95 1/20 0.46
ADORA2A P29274 1/20 0.45
PI4KA P42356 1/20 0.45
PI4K2B Q8TCG2 1/20 0.45
PI4K2A Q9BTU6 1/20 0.45
PI4KB Q9UBF8 1/20 0.45
NT5E P21589 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4236128 0.88 YTHDC1 (0.71) PDE8AYTHDC1PDE4APDE4BPDE4C
SCHEMBL822916 0.87 YTHDC1 (0.57) YTHDC1
SCHEMBL13596787 0.85 PDE8A (0.62) PDE8AYTHDC1PDE4APDE4BPDE4C
SCHEMBL1146681 0.83 YTHDC1 (0.67) PDE8AYTHDC1PDE4APDE4BPDE4C
SCHEMBL7204689 0.83 PDE8A (0.60) PDE8AYTHDC1PDE4APDE4BPDE4C
SCHEMBL2060472 0.82 PDE4A (0.67) PDE8AYTHDC1PDE4APDE4BPDE4C
SCHEMBL21076723 0.81 PDE8A (0.57) PDE8AYTHDC1PDE4APDE4BPDE4C
SCHEMBL15306090 0.80 NSD2 (0.46) YTHDC1PDE4APDE4BPDE4CPDE4D
SCHEMBL23764385 0.80 PDE8A (0.59) PDE8AYTHDC1PDE4APDE4BPDE4C
SCHEMBL822730 0.79 TLR7 (0.53) PDE8AYTHDC1PDE4APDE4BPDE4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260083853-A1 CD70 ANTIBODY DRUG CONJUGATES AND METHODS OF USING THE SAME GENMAB AS (DK) 2026-03-26 US disclosed
EP-4608451-A1 CD70 ANTIBODY DRUG CONJUGATES AND METHODS OF USING THE SAME Genmab A/S (DK) 2025-09-03 EP disclosed
WO-2025040743-A1 CONJUGATED TLR7 AND RIG-I AGONISTS UNIVERZA V LJUBLJANI (SI) 2025-02-27 WO disclosed
US-20240261427-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PROFOUNDBIO US CO. 2024-08-08 US disclosed
US-20240245796-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PROFOUNDBIO US CO. 2024-07-25 US disclosed
US-20240207429-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME WILMINGTON TRUST, NATIONAL ASSOCIATION 2024-06-27 US disclosed
US-20240207418-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PROFOUNDBIO US CO. 2024-06-27 US disclosed
WO-2024092067-A1 CD70 ANTIBODY DRUG CONJUGATES AND METHODS OF USING THE SAME PROFOUNDBIO US CO. (US) 2024-05-02 WO disclosed
US-20230382886-A1 CONJUGATED TLR7 AND NOD2 AGONISTS UNIVERZA V LJUBLJANI (SI) 2023-11-30 US disclosed
US-20230382886-A1 CONJUGATED TLR7 AND NOD2 AGONISTS UNIVERZA V LJUBLJANI (SI) 2023-11-30 US disclosed
US-20120009247-A1 PHOSPHOLIPID DRUG ANALOGS BIOPHARMA CREDIT PLC (GB) 2012-01-12 US disclosed
US-20120009247-A1 PHOSPHOLIPID DRUG ANALOGS BIOPHARMA CREDIT PLC (GB) 2012-01-12 US disclosed
US-20120003298-A1 METHODS FOR INDUCING AN IMMUNE RESPONSE TELORMEDIX SA (CH) 2012-01-05 US disclosed
US-20120003298-A1 METHODS FOR INDUCING AN IMMUNE RESPONSE TELORMEDIX SA (CH) 2012-01-05 US disclosed
WO-2011134669-A1 METHODS FOR INDUCING AN IMMUNE RESPONSE TELORMEDIX SA (CH) 2011-11-03 WO disclosed
WO-2011134668-A1 PHOSPHOLIPID DRUG ANALOGS TELORMEDIX SA (CH) 2011-11-03 WO disclosed
CN-101790380-A The conjugate and the application thereof of synthetic TLR agonist UNIV CALIFORNIA 2010-07-28 CN disclosed
US-20090324551-A1 TLR AGONISTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OFFICE OF TECHNOLOGY TRANSFER (US) 2009-12-31 US disclosed
CN-101304748-A Tlr agonists UNIV CALIFORNIA (US) 2008-11-12 CN disclosed
WO-2007024707-A2 TLR AGONISTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-03-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120003298-A1 METHODS FOR INDUCING AN IMMUNE RESPONSE CD4, IL4, CCR4 PDE8A 2008/4885YTHDC1 3866/4885PDE4A 2156/4885
US-20260083853-A1 CD70 ANTIBODY DRUG CONJUGATES AND METHODS OF USING THE SAME CD74, HACD3, FCGR2A PDE8A 4351/4885YTHDC1 2516/4885PDE4A 4568/4885
US-20090324551-A1 TLR AGONISTS TLR3, TLR1, TLR5 PDE8A 2214/4885YTHDC1 3900/4885PDE4A 1351/4885
US-20230382886-A1 CONJUGATED TLR7 AND NOD2 AGONISTS NOD2, TLR7, TLR9 PDE8A 941/4885YTHDC1 3725/4885PDE4A 914/4885
US-20240207418-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PAICS, DHFR, CD44 PDE8A 3659/4885YTHDC1 4323/4885PDE4A 4507/4885
US-20240207429-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PAICS, DHFR, CD44 PDE8A 3659/4885YTHDC1 4323/4885PDE4A 4507/4885
US-20240261427-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PAICS, DHFR, CD44 PDE8A 3659/4885YTHDC1 4323/4885PDE4A 4507/4885
US-20120009247-A1 PHOSPHOLIPID DRUG ANALOGS PHOSPHO1, PXMP4, SGMS1 PDE8A 588/4885YTHDC1 4672/4885PDE4A 157/4885
US-20240245796-A1 LINKERS, DRUG LINKERS AND CONJUGATES THEREOF AND METHODS OF USING THE SAME PAICS, DHFR, CD44 PDE8A 3659/4885YTHDC1 4323/4885PDE4A 4507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.