Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8A | O60658 | 10/20 | 0.60 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.53 |
| ▸ | YTHDC1 | Q96MU7 | 3/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | PI4KA | P42356 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596787 | 0.89 | PDE8A (0.62) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21977339 | 0.87 | CDK1 (0.57) | PDE4APDE4BPDE4CPDE4DHDAC4 | |
| SCHEMBL1146681 | 0.86 | YTHDC1 (0.67) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2060472 | 0.86 | PDE4A (0.67) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5461215 | 0.86 | HDAC6 (0.60) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL21076723 | 0.84 | PDE8A (0.57) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23764385 | 0.83 | PDE8A (0.59) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL822875 | 0.83 | PDE8A (0.56) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2060105 | 0.82 | PDE8A (0.55) | PDE8APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3959823 | 0.81 | PDE8A (0.67) | PDE8APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1035123-B1 | NOVEL HETEROCYCLIC COMPOUNDS | SUMITOMO PHARMA (JP) | 2003-08-20 | — | — | EP | disclosed |
| US-6329381-B1 | INTERFERONS, VIRICIDES AND ANTICARCINOGENIC AGENTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1035123-A1 | NOVEL HETEROCYCLIC COMPOUNDS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-09-13 | — | — | EP | disclosed |