Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
| ▸ | GBA1 | P04062 | 3/20 | 0.53 |
| ▸ | GLB1 | P16278 | 3/20 | 0.53 |
| ▸ | EDNRA | P25101 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.50 |
| ▸ | FUCA1 | P04066 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13655537 | 0.93 | HDAC4 (0.56) | HDAC4HDAC10HDAC6HDAC5GBA1 | |
| SCHEMBL4139459 | 0.86 | HDAC4 (0.75) | HDAC4HDAC10HDAC6HDAC5GBA1 | |
| SCHEMBL4126957 | 0.86 | HDAC4 (0.71) | HDAC4HDAC10HDAC6HDAC5GBA1 | |
| SCHEMBL14645022 | 0.85 | HDAC4 (0.61) | HDAC4HDAC10HDAC6HDAC5GBA1 | |
| SCHEMBL4142506 | 0.85 | HDAC4 (0.77) | HDAC4HDAC10HDAC6HDAC5GBA1 | |
| SCHEMBL10002024 | 0.82 | HDAC4 (0.67) | HDAC4HDAC10HDAC6HDAC5GBA1 | |
| SCHEMBL23964395 | 0.81 | HDAC4 (0.69) | HDAC4HDAC10HDAC6HDAC5GBA1 | |
| SCHEMBL12502117 | 0.81 | HDAC4 (0.65) | HDAC4HDAC10HDAC6HDAC5GBA1 | |
| SCHEMBL4782146 | 0.81 | HDAC4 (0.69) | HDAC4HDAC10HDAC6HDAC5GBA1 | |
| SCHEMBL29376225 | 0.81 | HDAC4 (0.69) | HDAC4HDAC10HDAC6HDAC5GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2793027-B1 | Unnatural reactive amino acid genetic code additions | SCRIPPS RESEARCH INST (US) | 2019-11-13 | — | — | EP | disclosed |
| US-10188605-B2 | Nanoparticles and nanoparticle compositions | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2019-01-29 | — | — | US | disclosed |
| EP-2770053-B1 | In vivo incorporation of alkynyl amino acids into proteins in eubacteria | SCRIPPS RESEARCH INST (US) | 2018-02-21 | — | — | EP | disclosed |
| US-9797908-B2 | Unnatural reactive amino acid genetic code additions | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-10-24 | — | — | US | disclosed |
| US-9797908-B2 | Unnatural reactive amino acid genetic code additions | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-10-24 | — | — | US | disclosed |
| US-9580721-B2 | Expanding the eukaryotic genetic code | The Scripps Reserach Institute (US) | 2017-02-28 | — | — | US | disclosed |
| US-9580721-B2 | Expanding the eukaryotic genetic code | The Scripps Reserach Institute (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160271061-A1 | NANOPARTICLES AND NANOPARTICLE COMPOSITIONS | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2016-09-22 | — | — | US | disclosed |
| US-20160271061-A1 | NANOPARTICLES AND NANOPARTICLE COMPOSITIONS | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2016-09-22 | — | — | US | disclosed |
| US-9320713-B2 | Nanoparticles and nanoparticle compositions | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2016-04-26 | — | — | US | disclosed |
| US-20080220472-A1 | Orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases incorporate para-propargyloxyphenylalanine into proteins produced in E. coli | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-09-11 | — | — | US | disclosed |
| US-20080176277-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-07-24 | — | — | US | disclosed |
| US-20080176277-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-07-24 | — | — | US | disclosed |
| US-20070166791-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-19 | — | — | US | disclosed |
| US-20070166791-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-19 | — | — | US | disclosed |
| US-20070154952-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-05 | — | — | US | disclosed |
| US-20070154952-A1 | Expanding the eukaryotic genetic code | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-05 | — | — | US | disclosed |
| US-20070060658-A1 | STABILIZATION OF ORGANOGELS AND HYDROGELS BY AZIDE-ALKYNE [3+2] CYCLOADDITION | THE SCRIPPS RESEARCH INSTITUTE | 2007-03-15 | — | — | US | disclosed |
| US-20070060658-A1 | STABILIZATION OF ORGANOGELS AND HYDROGELS BY AZIDE-ALKYNE [3+2] CYCLOADDITION | THE SCRIPPS RESEARCH INSTITUTE | 2007-03-15 | — | — | US | disclosed |
| WO-2007027493-A2 | STABILIZATION OF ORGANOGELS AND HYDROGELS BY AZIDE-ALKYNE[2+3] CYCLOADDITION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070154952-A1 | Expanding the eukaryotic genetic code | NSUN3, AARS1, TRMT1 | HDAC4 4142/4885HDAC10 2630/4885HDAC6 1775/4885 |
| US-10188605-B2 | Nanoparticles and nanoparticle compositions | MCM6, MPI, MSH2 | HDAC4 1982/4885HDAC10 3320/4885HDAC6 2261/4885 |
| US-20160271061-A1 | NANOPARTICLES AND NANOPARTICLE COMPOSITIONS | MCM6, MPI, MSH2 | HDAC4 1982/4885HDAC10 3320/4885HDAC6 2261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.