SCHEMBL1360134

SCHEMBL1360134

C=CCNC(=O)c1c(I)c(N)c(I)c(C(=O)NCC=C)c1I

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HPGD P15428 7/20 0.47
ALDH1A1 P00352 3/20 0.47
SMN1; SMN2 Q16637 2/20 0.41
RAB9A P51151 2/20 0.41
CYP1A2 P05177 2/20 0.39
LMNA P02545 2/20 0.39
ALOX15 P16050 1/20 0.38
PKM P14618 1/20 0.38
MAPT P10636 2/20 0.38
POLB P06746 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C19 P33261 1/20 0.37
TSHR P16473 1/20 0.37
TP53 P04637 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6013194 0.95 HPGD (0.44) HPGDALDH1A1SMN1; SMN2RAB9ACYP1A2
SCHEMBL9259815 0.94 HPGD (0.43) HPGDALDH1A1SMN1; SMN2RAB9ACYP1A2
SCHEMBL709348 0.92 HPGD (0.45) HPGDALDH1A1SMN1; SMN2RAB9ACYP1A2
SCHEMBL9614726 0.89 HPGD (0.40) HPGDALDH1A1SMN1; SMN2RAB9ACYP1A2
SCHEMBL9564059 0.79 HPGD (0.45) HPGDALDH1A1SMN1; SMN2RAB9ACYP1A2
SCHEMBL9563923 0.77 ALDH1A1 (0.43) HPGDALDH1A1SMN1; SMN2RAB9ACYP1A2
SCHEMBL9257402 0.77
SCHEMBL7045870 0.77 HPGD (0.43) HPGDALDH1A1SMN1; SMN2RAB9ACYP1A2
SCHEMBL3060111 0.76 HPGD (0.42) HPGDALDH1A1SMN1; SMN2RAB9ACYP1A2
SCHEMBL9563934 0.74 HPGD (0.41) HPGDALDH1A1SMN1; SMN2RAB9ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923537-B1 PROCESS FOR THE PREPARATION OF CONTRAST AGENTS NYCOMED IMAGING AS (NO) 2001-10-31 EP claimed
US-8066970-B2 Contrast agents GE HEALTHCARE AS (NO) 2011-11-29 US disclosed
US-8066970-B2 Contrast agents GE HEALTHCARE AS (NO) 2011-11-29 US disclosed
US-8066970-B2 Contrast agents GE HEALTHCARE AS (NO) 2011-11-29 US disclosed
US-20090098059-A1 CONTRAST AGENTS WYNN DUNCAN 2009-04-16 US disclosed
US-20070264201-A1 Contrast Agents GE HEALTHCARE LIMITED (NO) 2007-11-15 US disclosed
US-20070264201-A1 Contrast Agents GE HEALTHCARE LIMITED (NO) 2007-11-15 US disclosed
US-20070264201-A1 Contrast Agents GE HEALTHCARE LIMITED (NO) 2007-11-15 US disclosed
EP-0923537-B1 PROCESS FOR THE PREPARATION OF CONTRAST AGENTS NYCOMED IMAGING AS (NO) 2001-10-31 EP disclosed
EP-0160036-A4 NOVEL SYNTHETIC METHODS FOR NON-IONIC RADIOGRAPHIC CONTRAST MEDIA. BIOPHYSICA FOUNDATION (US) 1987-06-11 EP disclosed
EP-0160036-A1 NOVEL SYNTHETIC METHODS FOR NON-IONIC RADIOGRAPHIC CONTRAST MEDIA BIOPHYSICA FOUNDATION (US) 1985-11-06 EP disclosed
WO-1985001727-A1 NOVEL SYNTHETIC METHODS FOR NON-IONIC RADIOGRAPHIC CONTRAST MEDIA BIOPHYSICA FOUNDATION (US) 1985-04-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090098059-A1 CONTRAST AGENTS IPO4, IPO11, IPO8 HPGD 2630/4885ALDH1A1 4130/4885SMN1; SMN2 4565/4885
US-20070264201-A1 Contrast Agents TPO, IPO4, IPO11 HPGD 2130/4885ALDH1A1 3300/4885SMN1; SMN2 4845/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.