Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601372 | 0.91 | CHRM2 (0.41) | NPC1SMN1; SMN2ALDH1A1HRH3KMT2A | |
| SCHEMBL13601418 | 0.86 | POLB (0.46) | NPC1SMN1; SMN2ALDH1A1HRH3KMT2A | |
| SCHEMBL12772770 | 0.85 | GNAI3 (0.38) | SMN1; SMN2ALDH1A1TSHRL3MBTL1KMT2A | |
| SCHEMBL8259120 | 0.83 | HPGD (0.49) | SMN1; SMN2ALDH1A1L3MBTL1HRH3KMT2A | |
| SCHEMBL13601612 | 0.82 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1TSHRL3MBTL1HRH3 | |
| SCHEMBL12772809 | 0.81 | BDKRB1 (0.37) | SMN1; SMN2ALDH1A1TSHRL3MBTL1HRH3 | |
| SCHEMBL13608459 | 0.81 | HRH3 (0.42) | SMN1; SMN2ALDH1A1HRH3KMT2AHPGD | |
| SCHEMBL13601370 | 0.81 | NAAA (0.50) | L3MBTL1HRH3HPGD | |
| SCHEMBL19884745 | 0.80 | NPC1 (0.46) | NPC1SMN1; SMN2ALDH1A1L3MBTL1HRH3 | |
| SCHEMBL13601633 | 0.80 | NPC1 (0.55) | NPC1SMN1; SMN2ALDH1A1TSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |