Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601415 | 0.92 | POLB (0.48) | POLBHTTHRH3KMT2ANPC1 | |
| SCHEMBL13713306 | 0.88 | SMN1; SMN2 (0.43) | POLBHTTHRH3SMN1; SMN2DNM1 | |
| SCHEMBL12881387 | 0.86 | GNAI3 (0.40) | SMN1; SMN2DNM1ALDH1A1LMNA | |
| SCHEMBL13601375 | 0.86 | NPC1 (0.39) | POLBHRH3KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL13601405 | 0.84 | POLB (0.49) | POLBHTTHRH3KMT2AKDM4E | |
| SCHEMBL13601506 | 0.84 | DNM1 (0.43) | HRH3KMT2ASMN1; SMN2DNM1ALDH1A1 | |
| SCHEMBL13601633 | 0.83 | NPC1 (0.55) | POLBHRH3KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL12774112 | 0.83 | TP53 (0.41) | HRH3SMN1; SMN2DNM1ALDH1A1 | |
| SCHEMBL13601407 | 0.82 | NAAA (0.47) | POLBHTTHRH3KMT2A | |
| SCHEMBL13601455 | 0.81 | POLB (0.51) | POLBHTTHRH3KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |