Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601407 | 0.94 | NAAA (0.47) | POLBHTTKMT2AHRH3 | |
| SCHEMBL13601455 | 0.91 | POLB (0.51) | POLBHTTKMT2AHRH3KDM4E | |
| SCHEMBL11598618 | 0.87 | DGKA (0.50) | KMT2AHRH3ALDH1A1LMNA | |
| SCHEMBL673095 | 0.87 | DGKA (0.50) | KMT2AHRH3ALDH1A1LMNA | |
| SCHEMBL13988120 | 0.87 | SMN1; SMN2 (0.42) | KMT2AHRH3ALDH1A1LMNA | |
| SCHEMBL13988121 | 0.85 | ACHE (0.43) | KMT2AHRH3ALDH1A1LMNAMEN1 | |
| SCHEMBL10036917 | 0.85 | HRH1 (0.45) | KMT2AHRH3ALDH1A1LMNAMEN1 | |
| SCHEMBL12881358 | 0.85 | GNAI3 (0.53) | KMT2AHRH3ALDH1A1LMNA | |
| SCHEMBL8259120 | 0.84 | HPGD (0.49) | KMT2AHPGDHRH3KDM4EALDH1A1 | |
| SCHEMBL13601418 | 0.84 | POLB (0.46) | POLBHTTKMT2AHRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |