Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601405 | 0.91 | POLB (0.49) | POLBHTTKMT2AALDH1A1HRH3 | |
| SCHEMBL13601407 | 0.88 | NAAA (0.47) | POLBHTTKMT2AHRH3 | |
| SCHEMBL13601396 | 0.87 | POLB (0.54) | POLBHTTSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL674334 | 0.86 | ALDH1A1 (0.46) | SMN1; SMN2KMT2AALDH1A1HRH3KDM4E | |
| SCHEMBL419258 | 0.86 | ALDH1A1 (0.46) | SMN1; SMN2KMT2AALDH1A1HRH3KDM4E | |
| SCHEMBL12881361 | 0.84 | GNAI3 (0.47) | POLBHTTSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL13988123 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2KMT2AALDH1A1HRH3TP53 | |
| SCHEMBL13601367 | 0.83 | ALDH1A1 (0.41) | POLBHTTSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL420320 | 0.83 | CHRM1 (0.46) | POLBSMN1; SMN2KMT2AALDH1A1HRH3 | |
| SCHEMBL13601415 | 0.83 | POLB (0.48) | POLBHTTSMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |