Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601498 | 0.91 | DNM1 (0.49) | DNM1TP53PAOXTHRATHRB | |
| SCHEMBL12881387 | 0.88 | GNAI3 (0.40) | DNM1TP53TSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL12774112 | 0.87 | TP53 (0.41) | DNM1TP53THRATHRBTSHR | |
| SCHEMBL12881471 | 0.87 | TP53 (0.41) | DNM1TP53THRATHRBTSHR | |
| SCHEMBL13601612 | 0.86 | ALDH1A1 (0.40) | DNM1PAOXTSHRL3MBTL1HRH3 | |
| SCHEMBL13601418 | 0.84 | POLB (0.46) | DNM1HRH3SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13713306 | 0.83 | SMN1; SMN2 (0.43) | DNM1TP53TSHRL3MBTL1HRH3 | |
| SCHEMBL13601497 | 0.83 | THRB (0.56) | TP53PAOXTHRATHRBL3MBTL1 | |
| SCHEMBL13601667 | 0.82 | TSHR (0.42) | DNM1TSHRL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL18068757 | 0.81 | THRB (0.51) | TP53PAOXTHRATHRBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |