Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601693 | 0.91 | MAPT (0.46) | MAPTNPC1GAAHRH3HPGD | |
| SCHEMBL13601680 | 0.84 | HPGD (0.56) | MAPTNPC1GAAHRH3HPGD | |
| SCHEMBL19884745 | 0.84 | NPC1 (0.46) | NPC1GAAHRH3HPGDALDH1A1 | |
| SCHEMBL12881477 | 0.84 | GNAI3 (0.42) | MAPTGAAALDH1A1L3MBTL1CHRM2 | |
| SCHEMBL13601729 | 0.83 | MAPT (0.39) | MAPTNPC1GAAHPGDALDH1A1 | |
| SCHEMBL13601682 | 0.82 | HPGD (0.50) | MAPTNPC1GAAHPGDALDH1A1 | |
| SCHEMBL12881484 | 0.81 | ACHE (0.41) | MAPTGAAHRH3ALDH1A1L3MBTL1 | |
| SCHEMBL13601676 | 0.81 | MAPT (0.53) | MAPTNPC1GAAHRH3HPGD | |
| SCHEMBL12881494 | 0.80 | L3MBTL1 (0.42) | MAPTGAAALDH1A1L3MBTL1CHRM2 | |
| SCHEMBL13601633 | 0.78 | NPC1 (0.55) | NPC1HRH3HPGDALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |