Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601703 | 0.83 | MAPT (0.48) | MAPTGAAALDH1A1KDM4ETDP1 | |
| SCHEMBL13601717 | 0.79 | MAPT (0.59) | MAPTHTR1AGAAALDH1A1KDM4E | |
| SCHEMBL13601395 | 0.77 | TSHR (0.38) | ALDH1A1KDM4ETDP1CYP1A2POLB | |
| SCHEMBL13601528 | 0.75 | TP53 (0.43) | MAPTALDH1A1KDM4ETP53POLB | |
| SCHEMBL28404629 | 0.75 | ALDH1A1 (0.60) | MAPTGAAALDH1A1KDM4EPKM | |
| SCHEMBL13601554 | 0.73 | MAPT (0.46) | MAPTGAAALDH1A1KDM4EPKM | |
| SCHEMBL8823319 | 0.73 | ALDH1A1 (0.40) | MAPTALDH1A1KDM4ETP53CYP2C19 | |
| SCHEMBL12496523 | 0.71 | MAPT (0.67) | MAPTGAAALDH1A1KDM4EPKM | |
| SCHEMBL7378205 | 0.71 | ALDH1A1 (0.44) | MAPTGAAALDH1A1KDM4EPKM | |
| SCHEMBL1469974 | 0.69 | ALDH1A1 (0.52) | MAPTGAAALDH1A1KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |