Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13601737 | 0.83 | MAPT (0.40) | MAPTGAAL3MBTL1ALDH1A1POLB | |
| SCHEMBL13601675 | 0.80 | MAPT (0.70) | MAPTGAAL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL13601364 | 0.78 | MAPT (0.43) | MAPTGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL13601439 | 0.76 | POLB (0.43) | MAPTGAAL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL28404629 | 0.73 | ALDH1A1 (0.60) | MAPTGAAALDH1A1KDM4E | |
| SCHEMBL1267094 | 0.71 | GAA (0.65) | MAPTGAAL3MBTL1ALDH1A1POLB | |
| SCHEMBL12418600 | 0.71 | MAPT (0.49) | MAPTGAAL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL13601676 | 0.71 | MAPT (0.53) | MAPTGAAL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL13601680 | 0.69 | HPGD (0.56) | MAPTGAAL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL7378205 | 0.69 | ALDH1A1 (0.44) | MAPTGAAALDH1A1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |
| US-7625886-B2 | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-01 | — | — | US | disclosed |