Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27780413 | 0.81 | ALDH1A1 (0.51) | LMNAPOLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL25823072 | 0.75 | ALDH1A1 (0.43) | LMNAPOLBCYP1A2CYP2C19RAB9A | |
| SCHEMBL13600085 | 0.75 | HTT (0.40) | LMNAPOLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2938583 | 0.74 | MEN1 (0.69) | POLBCYP1A2CYP2C9CYP2C19RAB9A | |
| SCHEMBL14434720 | 0.73 | LMNA (0.44) | LMNAPOLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL26659276 | 0.73 | ALKBH1 (0.59) | LMNAPOLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15180443 | 0.72 | ALKBH1 (0.48) | LMNAPOLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16857585 | 0.70 | LMNA (0.56) | LMNAPOLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL17793830 | 0.69 | SLC6A7 (0.39) | CYP1A2L3MBTL1EGLN1 | |
| SCHEMBL21068095 | 0.69 | LMNA (0.70) | LMNAPOLBCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625905-B2 | Octahydro-pyrrolo[3,4-c]pyrrole CCR5 receptor antagonists | ROCHE PALO ALTO LLC (US) | 2009-12-01 | — | — | US | disclosed |