Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.48 |
| ▸ | PPARG | P37231 | 7/20 | 0.48 |
| ▸ | PPARD | Q03181 | 7/20 | 0.48 |
| ▸ | PPARA | Q07869 | 7/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TLR2 | O60603 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16491136 | 1.00 | ADRA1A (0.55) | ADRA1APRMT1TSHRLMNANFKB1 | |
| SCHEMBL4806320 | 0.91 | LMNA (0.46) | ADRA1APRMT1TSHRLMNANFKB1 | |
| SCHEMBL16491130 | 0.87 | EPHX2 (0.54) | ADRA1APRMT1TSHRLMNAHDAC11 | |
| SCHEMBL24722306 | 0.83 | PAOX (0.52) | ADRA1APRMT1ALDH1A1 | |
| SCHEMBL22456219 | 0.82 | ADRA1A (0.50) | ADRA1APRMT1TSHRLMNANFKB1 | |
| SCHEMBL26303080 | 0.82 | ADRA1A (0.37) | ADRA1APRMT1TSHRLMNANFKB1 | |
| SCHEMBL1983625 | 0.81 | LMNA (0.40) | ADRA1ATSHRLMNASLC22A6PLA2G2A | |
| SCHEMBL13884340 | 0.81 | POLB (0.38) | ADRA1APRMT1ALDH1A1MEN1KMT2A | |
| SCHEMBL14433610 | 0.81 | POLB (0.38) | ADRA1APRMT1ALDH1A1MEN1KMT2A | |
| SCHEMBL12664983 | 0.81 | POLB (0.38) | ADRA1APRMT1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220486-B2 | Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof | LA JOLLA INSTITUTE OF ALLERGY & IMMUNOLOGY (US) | 2022-01-11 | — | — | US | disclosed |
| US-20200290977-A1 | Inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase and Uses Thereof | LA JOLLA INSTITUTE OF ALLERGY & IMMUNOLOGY | 2020-09-17 | — | — | US | disclosed |
| US-10626094-B2 | Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-04-21 | — | — | US | disclosed |
| US-20170247340-A1 | Inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase and Uses Thereof | LA JOLLA INSTITUTE OF ALLERGY & IMMUNOLOGY | 2017-08-31 | — | — | US | disclosed |
| US-20170037059-A1 | GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-02-09 | — | — | US | disclosed |
| US-20170037059-A1 | GYRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-02-09 | — | — | US | disclosed |
| US-9481675-B2 | Gyrase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-11-01 | — | — | US | disclosed |
| US-20130079323-A1 | GYRASE INHIBITORS | TRIUS THERAPEUTICS, INC. (US) | 2013-03-28 | — | — | US | disclosed |
| US-20090280106-A1 | Pituitary adenylate cyclase acivating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use | BAYER PHARMACEUTICALS CORPORATION (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11220486-B2 | Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof | ACP1, PTPRCAP, PTPA | ADRA1A 4463/4885PRMT1 1459/4885TSHR 3240/4885 |
| US-10626094-B2 | Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof | ACP1, PTPRCAP, PTPA | ADRA1A 4463/4885PRMT1 1459/4885TSHR 3240/4885 |
| US-20090280106-A1 | Pituitary adenylate cyclase acivating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use | ADCYAP1R1, VIPR2, ADCY2 | ADRA1A 536/4885PRMT1 1246/4885TSHR 99/4885 |
| US-20170037059-A1 | GYRASE INHIBITORS | TOP1, CA7, TOP2B | ADRA1A 3879/4885PRMT1 848/4885TSHR 2940/4885 |
| US-20200290977-A1 | Inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase and Uses Thereof | ACP1, PTPRCAP, PTPA | ADRA1A 4463/4885PRMT1 1459/4885TSHR 3240/4885 |
| US-20130079323-A1 | GYRASE INHIBITORS | TOP1, CA7, TOP2B | ADRA1A 3879/4885PRMT1 848/4885TSHR 2940/4885 |
| US-20170247340-A1 | Inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase and Uses Thereof | ACP1, PTPRCAP, PTPA | ADRA1A 4463/4885PRMT1 1459/4885TSHR 3240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.